Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4820269..4820926 Replicon chromosome
Accession NZ_CP123642
Organism Klebsiella pneumoniae strain KpBSB53

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag QFW99_RS24235 Protein ID WP_002916310.1
Coordinates 4820516..4820926 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag QFW99_RS24230 Protein ID WP_002916312.1
Coordinates 4820269..4820535 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFW99_RS24205 (4815477) 4815477..4816910 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
QFW99_RS24210 (4817029) 4817029..4817757 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
QFW99_RS24215 (4817807) 4817807..4818118 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
QFW99_RS24220 (4818282) 4818282..4818941 + 660 WP_002916317.1 hemolysin III family protein -
QFW99_RS24225 (4819040) 4819040..4820023 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
QFW99_RS24230 (4820269) 4820269..4820535 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
QFW99_RS24235 (4820516) 4820516..4820926 + 411 WP_002916310.1 protein YgfX Toxin
QFW99_RS24240 (4820933) 4820933..4821454 - 522 WP_002916308.1 flavodoxin FldB -
QFW99_RS24245 (4821555) 4821555..4822451 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
QFW99_RS24250 (4822474) 4822474..4823187 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QFW99_RS24255 (4823193) 4823193..4824926 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T279109 WP_002916310.1 NZ_CP123642:4820516-4820926 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT279109 WP_002916312.1 NZ_CP123642:4820269-4820535 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References