Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 3961802..3962427 Replicon chromosome
Accession NZ_CP123642
Organism Klebsiella pneumoniae strain KpBSB53

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag QFW99_RS20005 Protein ID WP_002882817.1
Coordinates 3961802..3962185 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QFW99_RS20010 Protein ID WP_162557435.1
Coordinates 3962185..3962427 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFW99_RS19990 (3959168) 3959168..3960070 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
QFW99_RS19995 (3960067) 3960067..3960702 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
QFW99_RS20000 (3960699) 3960699..3961628 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
QFW99_RS20005 (3961802) 3961802..3962185 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
QFW99_RS20010 (3962185) 3962185..3962427 - 243 WP_162557435.1 CopG family transcriptional regulator Antitoxin
QFW99_RS20015 (3962632) 3962632..3963549 + 918 WP_032417884.1 alpha/beta hydrolase -
QFW99_RS20020 (3963564) 3963564..3964505 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
QFW99_RS20025 (3964550) 3964550..3964987 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
QFW99_RS20030 (3964984) 3964984..3965844 - 861 WP_004146232.1 virulence factor BrkB family protein -
QFW99_RS20035 (3965838) 3965838..3966437 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T279106 WP_002882817.1 NZ_CP123642:c3962185-3961802 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9557.79 Da        Isoelectric Point: 4.3509

>AT279106 WP_162557435.1 NZ_CP123642:c3962427-3962185 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNISRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure

References