Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3488745..3489261 Replicon chromosome
Accession NZ_CP123642
Organism Klebsiella pneumoniae strain KpBSB53

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag QFW99_RS17750 Protein ID WP_009309309.1
Coordinates 3488745..3489029 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag QFW99_RS17755 Protein ID WP_002886901.1
Coordinates 3489019..3489261 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFW99_RS17725 (3484228) 3484228..3484536 - 309 WP_019725542.1 PTS sugar transporter subunit IIB -
QFW99_RS17730 (3484621) 3484621..3484794 + 174 WP_019725541.1 hypothetical protein -
QFW99_RS17735 (3484797) 3484797..3485540 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
QFW99_RS17740 (3485897) 3485897..3488035 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
QFW99_RS17745 (3488277) 3488277..3488741 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QFW99_RS17750 (3488745) 3488745..3489029 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QFW99_RS17755 (3489019) 3489019..3489261 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QFW99_RS17760 (3489339) 3489339..3491249 - 1911 WP_004152270.1 PRD domain-containing protein -
QFW99_RS17765 (3491272) 3491272..3492426 - 1155 WP_002886900.1 lactonase family protein -
QFW99_RS17770 (3492493) 3492493..3493233 - 741 WP_032417761.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T279104 WP_009309309.1 NZ_CP123642:c3489029-3488745 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT279104 WP_002886901.1 NZ_CP123642:c3489261-3489019 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References