Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 3370564..3371374 Replicon chromosome
Accession NZ_CP123642
Organism Klebsiella pneumoniae strain KpBSB53

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag QFW99_RS17200 Protein ID WP_004178461.1
Coordinates 3370564..3371097 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag QFW99_RS17205 Protein ID WP_002887278.1
Coordinates 3371108..3371374 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFW99_RS17195 (3369395) 3369395..3370516 + 1122 WP_004214138.1 cupin domain-containing protein -
QFW99_RS17200 (3370564) 3370564..3371097 - 534 WP_004178461.1 type II toxin-antitoxin system toxin KacT Toxin
QFW99_RS17205 (3371108) 3371108..3371374 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
QFW99_RS17210 (3371477) 3371477..3372910 - 1434 WP_023283180.1 Cu(+)/Ag(+) sensor histidine kinase -
QFW99_RS17215 (3372900) 3372900..3373583 - 684 WP_004214143.1 copper response regulator transcription factor CusR -
QFW99_RS17220 (3373755) 3373755..3375140 + 1386 WP_032417819.1 efflux transporter outer membrane subunit -
QFW99_RS17225 (3375158) 3375158..3375463 + 306 WP_280620908.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T279102 WP_004178461.1 NZ_CP123642:c3371097-3370564 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT279102 WP_002887278.1 NZ_CP123642:c3371374-3371108 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References