Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 1353555..1355143 | Replicon | chromosome |
Accession | NZ_CP123642 | ||
Organism | Klebsiella pneumoniae strain KpBSB53 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | - |
Locus tag | QFW99_RS07295 | Protein ID | WP_032417112.1 |
Coordinates | 1353555..1354877 (-) | Length | 441 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | - |
Locus tag | QFW99_RS07300 | Protein ID | WP_032417111.1 |
Coordinates | 1354877..1355143 (-) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QFW99_RS07280 (1348611) | 1348611..1351112 | + | 2502 | WP_016831617.1 | fimbria/pilus outer membrane usher protein | - |
QFW99_RS07285 (1351100) | 1351100..1352104 | + | 1005 | WP_004176196.1 | fimbrial protein | - |
QFW99_RS07290 (1352246) | 1352246..1353538 | + | 1293 | WP_002904794.1 | glycoside hydrolase family 10 protein | - |
QFW99_RS07295 (1353555) | 1353555..1354877 | - | 1323 | WP_032417112.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
QFW99_RS07300 (1354877) | 1354877..1355143 | - | 267 | WP_032417111.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
QFW99_RS07305 (1355408) | 1355408..1355734 | - | 327 | WP_002904788.1 | hydroxyisourate hydrolase | - |
QFW99_RS07310 (1355731) | 1355731..1356231 | - | 501 | WP_002904787.1 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | - |
QFW99_RS07315 (1356209) | 1356209..1357588 | - | 1380 | WP_021440115.1 | nucleobase:cation symporter-2 family protein | - |
QFW99_RS07320 (1357934) | 1357934..1359088 | + | 1155 | WP_002904783.1 | FAD-dependent urate hydroxylase HpxO | - |
QFW99_RS07325 (1359069) | 1359069..1359992 | - | 924 | WP_002904781.1 | LysR family hpxDE operon transcriptional regulator HpxR | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49171.51 Da Isoelectric Point: 7.5357
>T279100 WP_032417112.1 NZ_CP123642:c1354877-1353555 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFFSHVWQAITENMLKLHARLQQGLQAL
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFFSHVWQAITENMLKLHARLQQGLQAL
Download Length: 1323 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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