Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1353555..1355143 Replicon chromosome
Accession NZ_CP123642
Organism Klebsiella pneumoniae strain KpBSB53

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag QFW99_RS07295 Protein ID WP_032417112.1
Coordinates 1353555..1354877 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QFW99_RS07300 Protein ID WP_032417111.1
Coordinates 1354877..1355143 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFW99_RS07280 (1348611) 1348611..1351112 + 2502 WP_016831617.1 fimbria/pilus outer membrane usher protein -
QFW99_RS07285 (1351100) 1351100..1352104 + 1005 WP_004176196.1 fimbrial protein -
QFW99_RS07290 (1352246) 1352246..1353538 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
QFW99_RS07295 (1353555) 1353555..1354877 - 1323 WP_032417112.1 type II toxin-antitoxin system HipA family toxin Toxin
QFW99_RS07300 (1354877) 1354877..1355143 - 267 WP_032417111.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QFW99_RS07305 (1355408) 1355408..1355734 - 327 WP_002904788.1 hydroxyisourate hydrolase -
QFW99_RS07310 (1355731) 1355731..1356231 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
QFW99_RS07315 (1356209) 1356209..1357588 - 1380 WP_021440115.1 nucleobase:cation symporter-2 family protein -
QFW99_RS07320 (1357934) 1357934..1359088 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
QFW99_RS07325 (1359069) 1359069..1359992 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.51 Da        Isoelectric Point: 7.5357

>T279100 WP_032417112.1 NZ_CP123642:c1354877-1353555 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFFSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9926.32 Da        Isoelectric Point: 8.5912

>AT279100 WP_032417111.1 NZ_CP123642:c1355143-1354877 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETASAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References