Detailed information of TA system TA027910

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 1839521..1840080
• Replicon: chromosome
• Accession: NC_018014
• Organism: Terriglobus roseus DSM 18391

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: TERRO_RS07685
• Protein ID: WP_014785435.1
• Coordinates: 1839712..1840080 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: I3ZF47
• Locus tag: TERRO_RS07680
• Protein ID: WP_014785434.1
• Coordinates: 1839521..1839715 (+)
• Length: 65 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TERRO_RS07650	1834808..1835017	+	210	WP_014785428.1	hypothetical protein	-
TERRO_RS07655	1835142..1835921	-	780	WP_014785429.1	hypothetical protein	-
TERRO_RS07660	1836043..1837107	+	1065	WP_014785430.1	hypothetical protein	-
TERRO_RS07665	1837159..1837806	+	648	WP_014785431.1	nitroreductase family protein	-
TERRO_RS07670	1837803..1838786	+	984	WP_014785432.1	alpha/beta hydrolase	-
TERRO_RS07675	1838787..1839413	-	627	WP_014785433.1	UbiX family flavin prenyltransferase	-
TERRO_RS07680	1839521..1839715	+	195	WP_014785434.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
TERRO_RS07685	1839712..1840080	+	369	WP_014785435.1	type II toxin-antitoxin system VapC family toxin	Toxin
TERRO_RS07690	1840077..1841894	-	1818	WP_014785436.1	lysine--tRNA ligase	-
TERRO_RS07695	1841958..1842206	+	249	WP_041593125.1	AtpZ/AtpI family protein	-
TERRO_RS07700	1842203..1842640	+	438	WP_157178590.1	hypothetical protein	-
TERRO_RS07705	1842712..1843443	+	732	WP_014785439.1	F0F1 ATP synthase subunit A	-
TERRO_RS07710	1843614..1843919	+	306	WP_041593126.1	ATP synthase F0 subunit C	-
TERRO_RS07715	1843995..1844909	-	915	WP_014785441.1	phosphatase PAP2 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13789.10 Da
• Isoelectric Point: 9.0031

>T27910 WP_014785435.1 NC_018014:1839712-1840080 [Terriglobus roseus DSM 18391]
VTLVDTSVWLDHLNTAVPSLARLLLKDEIMMHRYVIGEVAMGNWRRRSQTLADLNEMRQVMPATHSEVLQLVERHHLYGT
GIGYVDVHLLAAVRMTPGCDFWTRDKRLKTAATKLGIASPLV

Nucleotide

• Length: 369 bp

>T27910 NC_018014:1839712-1840080 [Terriglobus roseus DSM 18391]
GTGACGTTGGTCGACACCTCAGTCTGGCTGGACCACCTGAACACGGCCGTTCCGTCCCTGGCGCGGCTGCTTCTCAAGGA
CGAGATCATGATGCATCGATACGTCATTGGAGAGGTGGCAATGGGCAACTGGAGGCGACGTTCGCAGACGCTCGCCGACC
TGAACGAAATGCGTCAGGTAATGCCAGCCACGCACAGCGAAGTTCTCCAGCTCGTTGAGCGGCACCACCTTTACGGCACC
GGAATCGGCTACGTGGATGTGCATCTGCTCGCAGCCGTTCGGATGACGCCCGGCTGTGACTTTTGGACACGCGACAAGCG
GCTGAAAACAGCGGCGACGAAACTTGGGATCGCGTCGCCGCTCGTCTAG

Antitoxin

Protein

• Length: 65 a.a.
• Molecular weight: 6902.01 Da
• Isoelectric Point: 10.9487

>AT27910 WP_014785434.1 NC_018014:1839521-1839715 [Terriglobus roseus DSM 18391]
MRTTIVLDDELMERASEITGLSEKSAIVREALKALVAREAGRRLAALGGSAPDLKLPPRRRSAS

Nucleotide

• Length: 195 bp

>AT27910 NC_018014:1839521-1839715 [Terriglobus roseus DSM 18391]
ATGCGGACAACGATCGTTCTCGATGATGAGTTGATGGAGCGCGCGAGTGAGATCACCGGCTTGTCAGAAAAGTCGGCCAT
TGTCAGGGAGGCATTGAAGGCGCTCGTGGCCAGGGAAGCGGGGCGCAGGCTCGCCGCATTGGGTGGCAGCGCGCCAGATC
TGAAATTGCCTCCCCGGCGTCGGTCTGCATCGTGA

Structures

Antitoxin

• AlphaFold DB: I3ZF47