Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 23863..24599 Replicon plasmid unnamed
Accession NZ_CP123641
Organism Klebsiella pneumoniae strain KpBSB53

Toxin (Protein)


Gene name tacT Uniprot ID A0A8T5ZF70
Locus tag QFW99_RS00150 Protein ID WP_004187044.1
Coordinates 24117..24599 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag QFW99_RS00145 Protein ID WP_003026799.1
Coordinates 23863..24129 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFW99_RS00125 (QFW99_00125) 19012..19992 + 981 Protein_24 IS5-like element ISKpn26 family transposase -
QFW99_RS00130 (QFW99_00130) 20050..20295 + 246 WP_032238678.1 hypothetical protein -
QFW99_RS00135 (QFW99_00135) 20264..22849 + 2586 WP_004187040.1 EAL domain-containing protein -
QFW99_RS00140 (QFW99_00140) 23008..23712 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
QFW99_RS00145 (QFW99_00145) 23863..24129 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
QFW99_RS00150 (QFW99_00150) 24117..24599 + 483 WP_004187044.1 GNAT family N-acetyltransferase Toxin
QFW99_RS00155 (QFW99_00155) 24807..26153 + 1347 WP_077250283.1 ISNCY family transposase -
QFW99_RS00160 (QFW99_00160) 26212..27006 + 795 WP_004187050.1 tetratricopeptide repeat protein -
QFW99_RS00165 (QFW99_00165) 27045..28586 - 1542 WP_172884608.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..142324 142324
- inside IScluster/Tn - - 19012..26153 7141


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(46-148)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17280.93 Da        Isoelectric Point: 8.7197

>T279095 WP_004187044.1 NZ_CP123641:24117-24599 [Klebsiella pneumoniae]
VGCITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTYERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT279095 WP_003026799.1 NZ_CP123641:23863-24129 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References