Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 10446..10968 Replicon plasmid unnamed
Accession NZ_CP123641
Organism Klebsiella pneumoniae strain KpBSB53

Toxin (Protein)


Gene name stbE Uniprot ID A0A9J6S4Z8
Locus tag QFW99_RS00055 Protein ID WP_004187019.1
Coordinates 10446..10730 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4ZSR4
Locus tag QFW99_RS00060 Protein ID WP_004187025.1
Coordinates 10720..10968 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFW99_RS00035 (QFW99_00035) 5665..6129 - 465 WP_004187010.1 conjugative transfer protein MobI(A/C) -
QFW99_RS00040 (QFW99_00040) 7672..8085 + 414 WP_004187013.1 hypothetical protein -
QFW99_RS00045 (QFW99_00045) 8742..8993 + 252 Protein_8 conjugal transfer protein TraH -
QFW99_RS00050 (QFW99_00050) 9075..10430 + 1356 WP_004187017.1 ISNCY family transposase -
QFW99_RS00055 (QFW99_00055) 10446..10730 - 285 WP_004187019.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QFW99_RS00060 (QFW99_00060) 10720..10968 - 249 WP_004187025.1 plasmid stabilization protein Antitoxin
QFW99_RS00065 (QFW99_00065) 11258..11682 - 425 Protein_12 IS1 family transposase -
QFW99_RS00070 (QFW99_00070) 11870..11986 - 117 Protein_13 transposase domain-containing protein -
QFW99_RS00075 (QFW99_00075) 11931..12194 - 264 WP_004187027.1 transposase -
QFW99_RS00080 (QFW99_00080) 12209..12472 + 264 WP_004118208.1 hypothetical protein -
QFW99_RS00085 (QFW99_00085) 12716..12997 + 282 WP_013307885.1 helix-turn-helix domain-containing protein -
QFW99_RS00090 (QFW99_00090) 13032..13601 + 570 WP_004152117.1 small heat shock protein sHSP20 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..142324 142324
- flank IS/Tn - - 11222..11488 266


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11003.72 Da        Isoelectric Point: 10.5388

>T279094 WP_004187019.1 NZ_CP123641:c10730-10446 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTLQVQFKKKLKERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYRVEDDIVTVTVIGVGK
RENDDIYNATLNRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9011.24 Da        Isoelectric Point: 3.9947

>AT279094 WP_004187025.1 NZ_CP123641:c10968-10720 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFHAGDGAPVAILNRNEPAFYCVPPALYAQLMELLEDEELGRMADERSGEKVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4ZSR4

References