Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4829895..4830496 Replicon chromosome
Accession NZ_CP123607
Organism Serratia marcescens strain RMCH-M16-N

Toxin (Protein)


Gene name vapC Uniprot ID A0A0P0Q8I8
Locus tag QFB85_RS22980 Protein ID WP_004933929.1
Coordinates 4830116..4830496 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A086G6A0
Locus tag QFB85_RS22975 Protein ID WP_004933932.1
Coordinates 4829895..4830116 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFB85_RS22955 (QFB85_22955) 4825044..4826021 + 978 WP_197753766.1 glyoxylate/hydroxypyruvate reductase GhrB -
QFB85_RS22960 (QFB85_22960) 4826023..4826175 - 153 WP_015376155.1 hypothetical protein -
QFB85_RS22965 (QFB85_22965) 4826371..4828434 + 2064 WP_280631082.1 alpha-amylase -
QFB85_RS22970 (QFB85_22970) 4828570..4829820 + 1251 WP_280631083.1 valine--pyruvate transaminase -
QFB85_RS22975 (QFB85_22975) 4829895..4830116 + 222 WP_004933932.1 ribbon-helix-helix domain-containing protein Antitoxin
QFB85_RS22980 (QFB85_22980) 4830116..4830496 + 381 WP_004933929.1 type II toxin-antitoxin system VapC family toxin Toxin
QFB85_RS22985 (QFB85_22985) 4830507..4832165 - 1659 WP_004933926.1 putative transporter -
QFB85_RS22990 (QFB85_22990) 4832333..4832761 - 429 WP_004933922.1 small heat shock chaperone IbpB -
QFB85_RS22995 (QFB85_22995) 4832869..4833282 - 414 WP_004933919.1 small heat shock chaperone IbpA -
QFB85_RS23000 (QFB85_23000) 4833592..4833939 + 348 WP_004933911.1 YceK/YidQ family lipoprotein -
QFB85_RS23005 (QFB85_23005) 4833970..4835250 - 1281 WP_004933910.1 DUF3748 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-102)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14173.48 Da        Isoelectric Point: 7.3170

>T279090 WP_004933929.1 NZ_CP123607:4830116-4830496 [Serratia marcescens]
MVAQRALFDTNILIDYLNGIPQAKDVLTEYHTNPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIIWATAQVGFRTLISRNPKDFGTDNGVLMPYRL

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8593.53 Da        Isoelectric Point: 4.4791

>AT279090 WP_004933932.1 NZ_CP123607:4829895-4830116 [Serratia marcescens]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLTENHVEDPSNAFGLWSGAMGDGVDYENRQREEWE

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P0Q8I8

Antitoxin

Source ID Structure
AlphaFold DB A0A086G6A0

References