Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1078196..1078852 Replicon chromosome
Accession NZ_CP123607
Organism Serratia marcescens strain RMCH-M16-N

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QFB85_RS05040 Protein ID WP_021504433.1
Coordinates 1078463..1078852 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8G2LCA8
Locus tag QFB85_RS05035 Protein ID WP_004941563.1
Coordinates 1078196..1078459 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFB85_RS05015 (QFB85_05015) 1073234..1074448 - 1215 WP_015378743.1 D-galactonate dehydratase family protein -
QFB85_RS05020 (QFB85_05020) 1074617..1075522 - 906 WP_280631311.1 lipid kinase YegS -
QFB85_RS05025 (QFB85_05025) 1075989..1077341 - 1353 WP_280631312.1 tRNA 5-hydroxyuridine modification protein YegQ -
QFB85_RS05030 (QFB85_05030) 1077520..1077858 - 339 WP_004941561.1 YegP family protein -
QFB85_RS05035 (QFB85_05035) 1078196..1078459 + 264 WP_004941563.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
QFB85_RS05040 (QFB85_05040) 1078463..1078852 + 390 WP_021504433.1 type II toxin-antitoxin system VapC family toxin Toxin
QFB85_RS05045 (QFB85_05045) 1078860..1079576 - 717 WP_197753782.1 two-component system response regulator BaeR -
QFB85_RS05050 (QFB85_05050) 1079576..1080958 - 1383 WP_021504432.1 two-component system sensor histidine kinase BaeS -
QFB85_RS05055 (QFB85_05055) 1080955..1082385 - 1431 WP_280631313.1 multidrug transporter subunit MdtD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14398.63 Da        Isoelectric Point: 8.4983

>T279083 WP_021504433.1 NZ_CP123607:1078463-1078852 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELRYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RANMERKGKIMGAMDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10062.31 Da        Isoelectric Point: 4.6702

>AT279083 WP_004941563.1 NZ_CP123607:1078196-1078459 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References