Detailed information of TA system TA027908

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 983049..983653
• Replicon: chromosome
• Accession: NC_018013
• Organism: Aequorivita sublithincola DSM 14238

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: I3YTX8
• Locus tag: AEQSU_RS04645
• Protein ID: WP_014781704.1
• Coordinates: 983049..983294 (+)
• Length: 82 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: I3YTX9
• Locus tag: AEQSU_RS04650
• Protein ID: WP_014781705.1
• Coordinates: 983291..983653 (+)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AEQSU_RS04630	979232..980476	+	1245	WP_014781701.1	tryptophan 7-halogenase	-
AEQSU_RS04635	980473..981099	-	627	WP_014781702.1	hypothetical protein	-
AEQSU_RS04640	981207..982874	-	1668	WP_014781703.1	hypothetical protein	-
AEQSU_RS04645	983049..983294	+	246	WP_014781704.1	type II toxin-antitoxin system HicA family toxin	Toxin
AEQSU_RS04650	983291..983653	+	363	WP_014781705.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
AEQSU_RS04660	984177..987500	+	3324	WP_014781706.1	DUF2723 domain-containing protein	-
AEQSU_RS04665	987527..988171	+	645	WP_014781707.1	polysaccharide deacetylase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-80)

Antitoxin

• Uncharacterised protein family HicB (55-102)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9434.11 Da
• Isoelectric Point: 9.5331

>T27908 WP_014781704.1 NC_018013:983049-983294 [Aequorivita sublithincola DSM 14238]
MSKIEKLLDKLKSVPKDLTWDELVEILNFLDYCEITKKGKTGGSRVKFSNKENDIINLHKPHPSNIVKQYVIRPLLEKLE
L

Nucleotide

• Length: 246 bp

>T27908 NC_018013:983049-983294 [Aequorivita sublithincola DSM 14238]
ATGAGTAAAATTGAAAAACTTTTAGACAAGCTCAAAAGTGTTCCAAAAGATTTAACTTGGGACGAACTCGTAGAAATTTT
GAATTTTCTAGATTATTGTGAAATTACAAAAAAGGGAAAGACAGGAGGCTCAAGAGTAAAATTTTCAAATAAAGAAAACG
ACATTATAAATTTACACAAACCTCACCCATCTAATATAGTTAAACAATACGTTATTAGGCCACTATTAGAAAAATTAGAA
CTATGA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 13898.80 Da
• Isoelectric Point: 6.7147

>AT27908 WP_014781705.1 NC_018013:983291-983653 [Aequorivita sublithincola DSM 14238]
MTNYLKHKGYIRTVEYSAEDKCLYGKVIGINDLVNYEAQSVEDLTNSFNEAVEDYLKTCKQLGKEPDKYFKGVFNVRAGS
TRHRKLAIIADKKKMKLNELVNVAFDYLIKNEDEVLHEND

Nucleotide

• Length: 363 bp

>AT27908 NC_018013:983291-983653 [Aequorivita sublithincola DSM 14238]
ATGACAAATTATTTAAAACACAAAGGATATATCAGAACCGTTGAATATAGTGCTGAAGACAAATGTCTTTATGGAAAAGT
TATCGGTATAAATGATTTAGTGAATTATGAAGCGCAATCTGTTGAAGATTTAACAAATTCTTTTAATGAGGCCGTTGAAG
ACTATTTGAAAACTTGCAAACAATTGGGGAAAGAACCCGATAAATATTTTAAAGGAGTTTTTAATGTTCGTGCAGGTTCC
ACAAGACATAGAAAGCTTGCCATAATTGCAGATAAAAAGAAAATGAAGCTAAATGAATTGGTTAACGTTGCTTTTGACTA
CTTGATAAAAAATGAGGATGAGGTTTTACATGAAAATGATTGA

Structures

Toxin

• AlphaFold DB: I3YTX8

Antitoxin

• AlphaFold DB: I3YTX9