Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4671440..4672179 Replicon chromosome
Accession NZ_CP123598
Organism Enterobacter cloacae strain RMCH-M23-N

Toxin (Protein)


Gene name tacT Uniprot ID A0A9E6WPH7
Locus tag QFB83_RS22265 Protein ID WP_013087269.1
Coordinates 4671440..4671925 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A9E6WPN8
Locus tag QFB83_RS22270 Protein ID WP_007869691.1
Coordinates 4671913..4672179 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFB83_RS22235 (QFB83_22235) 4667811..4668008 + 198 WP_004152115.1 hypothetical protein -
QFB83_RS22240 (QFB83_22240) 4668246..4668392 + 147 Protein_4340 diguanylate cyclase -
QFB83_RS22245 (QFB83_22245) 4668507..4668995 + 489 WP_004152114.1 phosphate-starvation-inducible PsiE family protein -
QFB83_RS22250 (QFB83_22250) 4668982..4669944 + 963 WP_280596157.1 zinc metalloprotease HtpX -
QFB83_RS22255 (QFB83_22255) 4669969..4670100 - 132 WP_256025477.1 hypothetical protein -
QFB83_RS22260 (QFB83_22260) 4670121..4671286 + 1166 Protein_4344 IS3 family transposase -
QFB83_RS22265 (QFB83_22265) 4671440..4671925 - 486 WP_013087269.1 GNAT family N-acetyltransferase Toxin
QFB83_RS22270 (QFB83_22270) 4671913..4672179 - 267 WP_007869691.1 DUF1778 domain-containing protein Antitoxin
QFB83_RS22280 (QFB83_22280) 4673332..4673793 - 462 WP_224253942.1 fumarylacetoacetate hydrolase family protein -
QFB83_RS22285 (QFB83_22285) 4673883..4674050 + 168 Protein_4349 transposase -
QFB83_RS22290 (QFB83_22290) 4674069..4675037 - 969 WP_032665824.1 IS110 family transposase -
QFB83_RS22295 (QFB83_22295) 4675205..4676256 + 1052 Protein_4351 IS3 family transposase -
QFB83_RS22300 (QFB83_22300) 4676253..4676762 - 510 WP_004187073.1 DUF2778 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4662297..4679468 17171
- inside IScluster/Tn - - 4670259..4679468 9209


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-146)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17736.45 Da        Isoelectric Point: 9.5181

>T279077 WP_013087269.1 NZ_CP123598:c4671925-4671440 [Enterobacter cloacae]
VGRVTAPEPLSSSHQLAEFVSGEAVLDDWLKQRGLKNQALGAARTFVVCKRDTKQVVGFYSLATGSVNHVEAMGSLRRNM
PDPIPVIILARLAVDVSYRGQGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYLHHGFKASQTQERTLFLKLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10080.46 Da        Isoelectric Point: 4.3837

>AT279077 WP_007869691.1 NZ_CP123598:c4672179-4671913 [Enterobacter cloacae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVSDEAAIDKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References