Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA(toxin)
Location 4487994..4489777 Replicon chromosome
Accession NZ_CP123598
Organism Enterobacter cloacae strain RMCH-M23-N

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag QFB83_RS21425 Protein ID WP_057071286.1
Coordinates 4487994..4489343 (+) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QFB83_RS21430 Protein ID WP_029883072.1
Coordinates 4489340..4489777 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFB83_RS21395 (QFB83_21395) 4483149..4483946 - 798 WP_057071281.1 helix-turn-helix transcriptional regulator -
QFB83_RS21400 (QFB83_21400) 4484006..4484722 + 717 WP_280596069.1 type 1 glutamine amidotransferase -
QFB83_RS21405 (QFB83_21405) 4484914..4485312 + 399 WP_023619766.1 CidA/LrgA family protein -
QFB83_RS21410 (QFB83_21410) 4485309..4486004 + 696 WP_013097948.1 CidB/LrgB family autolysis modulator -
QFB83_RS21415 (QFB83_21415) 4486134..4487018 + 885 WP_057071284.1 cytidine deaminase -
QFB83_RS21420 (QFB83_21420) 4487146..4487859 + 714 WP_023619764.1 outer membrane permeability protein SanA -
QFB83_RS21425 (QFB83_21425) 4487994..4489343 + 1350 WP_057071286.1 HipA domain-containing protein Toxin
QFB83_RS21430 (QFB83_21430) 4489340..4489777 + 438 WP_029883072.1 helix-turn-helix transcriptional regulator Antitoxin
QFB83_RS21435 (QFB83_21435) 4489829..4490839 - 1011 WP_013097952.1 galactose/methyl galactoside ABC transporter permease MglC -
QFB83_RS21440 (QFB83_21440) 4490855..4492375 - 1521 WP_280596071.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
QFB83_RS21445 (QFB83_21445) 4492456..4493454 - 999 WP_014832691.1 galactose/glucose ABC transporter substrate-binding protein MglB -
QFB83_RS21450 (QFB83_21450) 4493750..4494772 - 1023 WP_038420198.1 HTH-type transcriptional regulator GalS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 51163.76 Da        Isoelectric Point: 4.5754

>T279076 WP_057071286.1 NZ_CP123598:4487994-4489343 [Enterobacter cloacae]
METLTVQAYLNETWTDIALIKYPGSEKNDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDQGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNEFARTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVDTMR
LEEGSHYPSLWLPRFDIVRNEQDQLIRLGMESVYSLLQKAPGTLLDHEATLRALINKITSSHMVQQQGYQFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENHIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNAIAQALAEWIPPTT
LLDALHETAVQLIDLPERLEARGVPDQIMEMPAIGFRYIPNKLSRWGLL

Download         Length: 1350 bp

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16218.68 Da        Isoelectric Point: 10.6347

>AT279076 WP_029883072.1 NZ_CP123598:4489340-4489777 [Enterobacter cloacae]
MKISNKSESELLQTLARVRSVNEKRRHDEDEDPDKSSVVKRQRVSSGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGMKQDEYAKLVSVSRKTLSDVENGRGNYSADIINKIFKPFGLQTGLVPISKSLIASLFT

Download         Length: 438 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References