Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2389340..2389960 Replicon chromosome
Accession NZ_CP123598
Organism Enterobacter cloacae strain RMCH-M23-N

Toxin (Protein)


Gene name Hha Uniprot ID A0A5E1A1U8
Locus tag QFB83_RS11425 Protein ID WP_013095889.1
Coordinates 2389340..2389558 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag QFB83_RS11430 Protein ID WP_008499288.1
Coordinates 2389586..2389960 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFB83_RS11395 (QFB83_11395) 2385352..2385612 + 261 WP_006176933.1 type B 50S ribosomal protein L31 -
QFB83_RS11400 (QFB83_11400) 2385615..2385755 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
QFB83_RS11405 (QFB83_11405) 2385752..2386462 - 711 WP_057071118.1 GNAT family protein -
QFB83_RS11410 (QFB83_11410) 2386564..2388024 + 1461 WP_057071117.1 PLP-dependent aminotransferase family protein -
QFB83_RS11415 (QFB83_11415) 2387996..2388463 - 468 WP_013095887.1 YlaC family protein -
QFB83_RS11420 (QFB83_11420) 2388579..2389130 - 552 WP_013095888.1 maltose O-acetyltransferase -
QFB83_RS11425 (QFB83_11425) 2389340..2389558 - 219 WP_013095889.1 HHA domain-containing protein Toxin
QFB83_RS11430 (QFB83_11430) 2389586..2389960 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
QFB83_RS11435 (QFB83_11435) 2390473..2393619 - 3147 WP_013095890.1 multidrug efflux RND transporter permease subunit AcrB -
QFB83_RS11440 (QFB83_11440) 2393642..2394835 - 1194 WP_023620093.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8625.98 Da        Isoelectric Point: 8.9008

>T279071 WP_013095889.1 NZ_CP123598:c2389558-2389340 [Enterobacter cloacae]
MSDKPLTKTDYLMRLRRCQSIDTLERVIEKNKYELSDNELTVFYSAADHRLAELTMNKLYDKIPPSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT279071 WP_008499288.1 NZ_CP123598:c2389960-2389586 [Enterobacter cloacae]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E1A1U8

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References