Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 1857988..1858564 Replicon chromosome
Accession NZ_CP123598
Organism Enterobacter cloacae strain RMCH-M23-N

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag QFB83_RS08980 Protein ID WP_280597388.1
Coordinates 1857988..1858275 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID -
Locus tag QFB83_RS08985 Protein ID WP_057072722.1
Coordinates 1858262..1858564 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFB83_RS08960 (QFB83_08960) 1853950..1854420 + 471 WP_013095432.1 MarR family transcriptional regulator -
QFB83_RS08965 (QFB83_08965) 1854417..1855484 + 1068 WP_100245169.1 HlyD family secretion protein -
QFB83_RS08970 (QFB83_08970) 1855474..1856550 + 1077 WP_013095434.1 DUF2955 domain-containing protein -
QFB83_RS08975 (QFB83_08975) 1856520..1857818 - 1299 WP_013095435.1 DUF445 domain-containing protein -
QFB83_RS08980 (QFB83_08980) 1857988..1858275 + 288 WP_280597388.1 BrnT family toxin Toxin
QFB83_RS08985 (QFB83_08985) 1858262..1858564 + 303 WP_057072722.1 BrnA antitoxin family protein Antitoxin
QFB83_RS08990 (QFB83_08990) 1858595..1859233 - 639 WP_129327048.1 LysE family translocator -
QFB83_RS08995 (QFB83_08995) 1859282..1860025 - 744 WP_057071674.1 AraC family transcriptional regulator -
QFB83_RS09000 (QFB83_09000) 1860163..1861533 + 1371 WP_038418628.1 NAD-dependent succinate-semialdehyde dehydrogenase -
QFB83_RS09005 (QFB83_09005) 1861575..1861895 - 321 WP_013095439.1 hypothetical protein -
QFB83_RS09010 (QFB83_09010) 1861895..1862440 - 546 WP_013095440.1 YfaZ family outer membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11233.60 Da        Isoelectric Point: 6.8813

>T279070 WP_280597388.1 NZ_CP123598:1857988-1858275 [Enterobacter cloacae]
MPTEYEWDSDKAKSNQQKHGIRFEDAVLVFDDPYHLSVQDRYENGEFRWQTIGLVQGVIIILVAHTVRFESGGEIIRIIS
ARKADRKERSRYEHR

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11418.04 Da        Isoelectric Point: 10.3694

>AT279070 WP_057072722.1 NZ_CP123598:1858262-1858564 [Enterobacter cloacae]
MSIVKHKRGSSPEVSARRDAELKALAEKTEAEIDYSDIPATDDKQWSGAVRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References