Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1817051..1817567 Replicon chromosome
Accession NZ_CP123598
Organism Enterobacter cloacae strain RMCH-M23-N

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag QFB83_RS08800 Protein ID WP_045292395.1
Coordinates 1817283..1817567 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V3EXX3
Locus tag QFB83_RS08795 Protein ID WP_008501400.1
Coordinates 1817051..1817293 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFB83_RS08780 (QFB83_08780) 1813040..1813780 + 741 WP_057071447.1 KDGP aldolase family protein -
QFB83_RS08785 (QFB83_08785) 1813904..1815043 + 1140 WP_100168201.1 lactonase family protein -
QFB83_RS08790 (QFB83_08790) 1815063..1816973 + 1911 WP_280597354.1 PRD domain-containing protein -
QFB83_RS08795 (QFB83_08795) 1817051..1817293 + 243 WP_008501400.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QFB83_RS08800 (QFB83_08800) 1817283..1817567 + 285 WP_045292395.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QFB83_RS08805 (QFB83_08805) 1817571..1818035 - 465 WP_057071444.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QFB83_RS08810 (QFB83_08810) 1818158..1820296 - 2139 WP_013095357.1 anaerobic ribonucleoside-triphosphate reductase -
QFB83_RS08815 (QFB83_08815) 1820670..1822313 - 1644 WP_280597359.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10945.83 Da        Isoelectric Point: 10.4610

>T279069 WP_045292395.1 NZ_CP123598:1817283-1817567 [Enterobacter cloacae]
MTYELEFDPRALKEWSKLGETVKKQFRKKLAGVLVNPRIESARLHTLPDCYKIKLRSQGYRLVYQVQDNVVTVVVIAIGK
REKSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8972.37 Da        Isoelectric Point: 5.0651

>AT279069 WP_008501400.1 NZ_CP123598:1817051-1817293 [Enterobacter cloacae]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDALIQTVRERLANPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V3EXX3

References