Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1486157..1486761 Replicon chromosome
Accession NZ_CP123598
Organism Enterobacter cloacae strain RMCH-M23-N

Toxin (Protein)


Gene name hicA Uniprot ID A0A421IJD5
Locus tag QFB83_RS07220 Protein ID WP_071843252.1
Coordinates 1486157..1486342 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A5E1AFC9
Locus tag QFB83_RS07225 Protein ID WP_023621194.1
Coordinates 1486357..1486761 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFB83_RS07205 (QFB83_07205) 1482588..1484126 + 1539 WP_280597218.1 aldehyde dehydrogenase family protein -
QFB83_RS07210 (QFB83_07210) 1484123..1485088 - 966 WP_061771396.1 LysR family transcriptional regulator -
QFB83_RS07215 (QFB83_07215) 1485206..1485946 + 741 WP_013094942.1 MipA/OmpV family protein -
QFB83_RS07220 (QFB83_07220) 1486157..1486342 + 186 WP_071843252.1 type II toxin-antitoxin system HicA family toxin Toxin
QFB83_RS07225 (QFB83_07225) 1486357..1486761 + 405 WP_023621194.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QFB83_RS07230 (QFB83_07230) 1486815..1488770 - 1956 WP_062730039.1 glycoside hydrolase family 127 protein -
QFB83_RS07235 (QFB83_07235) 1488781..1490181 - 1401 WP_057071744.1 MFS transporter -
QFB83_RS07240 (QFB83_07240) 1490406..1491224 + 819 WP_020686525.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6859.08 Da        Isoelectric Point: 11.7891

>T279067 WP_071843252.1 NZ_CP123598:1486157-1486342 [Enterobacter cloacae]
VKSADVITVLVRHGWKCVRTKGSHHQFRHPVHAGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14888.72 Da        Isoelectric Point: 4.3036

>AT279067 WP_023621194.1 NZ_CP123598:1486357-1486761 [Enterobacter cloacae]
MFYPAYIHSDPDGSASGFFPDVPGCFFAGNSLDDAFQDARDALTAHFEALFEMDEELPLPGNVEAHLEATPGDFIGGQWL
LVDINMKQFDGKAERINITLPRRLLVKIDSFVSEHPQFSNRSAFLAEAARRVLP

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A421IJD5

Antitoxin

Source ID Structure
AlphaFold DB A0A5E1AFC9

References