Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 1353781..1354443 Replicon chromosome
Accession NZ_CP123598
Organism Enterobacter cloacae strain RMCH-M23-N

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QFB83_RS06590 Protein ID WP_020686448.1
Coordinates 1354045..1354443 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A5E1AFU3
Locus tag QFB83_RS06585 Protein ID WP_020686447.1
Coordinates 1353781..1354041 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFB83_RS06570 (QFB83_06570) 1351207..1352328 - 1122 WP_057072238.1 efflux RND transporter periplasmic adaptor subunit -
QFB83_RS06575 (QFB83_06575) 1352477..1353046 - 570 WP_013094828.1 TetR/AcrR family transcriptional regulator -
QFB83_RS06580 (QFB83_06580) 1353234..1353653 + 420 WP_038418282.1 GNAT family N-acetyltransferase -
QFB83_RS06585 (QFB83_06585) 1353781..1354041 + 261 WP_020686447.1 virulence protein Antitoxin
QFB83_RS06590 (QFB83_06590) 1354045..1354443 + 399 WP_020686448.1 type II toxin-antitoxin system VapC family toxin Toxin
QFB83_RS06595 (QFB83_06595) 1354584..1355384 + 801 WP_029881865.1 lipoprotein NlpA -
QFB83_RS06600 (QFB83_06600) 1355397..1356077 - 681 WP_029881866.1 EAL domain-containing protein -
QFB83_RS06605 (QFB83_06605) 1356146..1356757 - 612 WP_013094832.1 LuxR C-terminal-related transcriptional regulator -
QFB83_RS06610 (QFB83_06610) 1357205..1357870 + 666 WP_020686451.1 LuxR C-terminal-related transcriptional regulator -
QFB83_RS06615 (QFB83_06615) 1357912..1358976 - 1065 WP_020686452.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14855.11 Da        Isoelectric Point: 6.7510

>T279066 WP_020686448.1 NZ_CP123598:1354045-1354443 [Enterobacter cloacae]
MLHMLDTNIVSHLVRQHPGVIKHYSRTPIEKMCISSVTEAELLYGIAKKQSDRLQKTILEFLKTITICDWDSEAAATYGE
LRAEMEKRGRVMGDLDQLIAAHALSRGTTIVTNDHAFRMVQALAVEDWTTAS

Download         Length: 399 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10289.66 Da        Isoelectric Point: 10.0393

>AT279066 WP_020686447.1 NZ_CP123598:1353781-1354041 [Enterobacter cloacae]
MKRTAKLFKKGRRQAVMLPADFMFDTESVYIRRDEEGNVILTARSEKERHRDNFLRLLKQTDVPDSFLSKEERNQSYTTR
DPFEGF

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5E1AFU3

References