279064

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yafW-ykfI/CbtA-CbeA
Location 501279..501958 Replicon chromosome
Accession NZ_CP123598
Organism Enterobacter cloacae strain RMCH-M23-N

Toxin (Protein)


Gene name ykfI Uniprot ID A0A7I6XXA8
Locus tag QFB83_RS02455 Protein ID WP_039025449.1
Coordinates 501279..501620 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yafW Uniprot ID -
Locus tag QFB83_RS02460 Protein ID WP_280596645.1
Coordinates 501641..501958 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFB83_RS02435 (QFB83_02435) 496550..498295 + 1746 WP_014833324.1 DNA primase -
QFB83_RS02440 (QFB83_02440) 498461..500308 + 1848 WP_013098777.1 RNA polymerase sigma factor RpoD -
QFB83_RS02445 (QFB83_02445) 500410..500916 - 507 WP_020689452.1 G/U mismatch-specific DNA glycosylase -
QFB83_RS02455 (QFB83_02455) 501279..501620 - 342 WP_039025449.1 TA system toxin CbtA family protein Toxin
QFB83_RS02460 (QFB83_02460) 501641..501958 - 318 WP_280596645.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QFB83_RS02465 (QFB83_02465) 501977..502198 - 222 WP_039025447.1 DUF987 domain-containing protein -
QFB83_RS02470 (QFB83_02470) 502207..502350 - 144 Protein_476 JAB domain-containing protein -
QFB83_RS02475 (QFB83_02475) 502390..502848 - 459 WP_039025446.1 antirestriction protein -
QFB83_RS02480 (QFB83_02480) 502950..503189 - 240 WP_039025445.1 DUF905 domain-containing protein -
QFB83_RS02485 (QFB83_02485) 503266..503733 - 468 WP_039025444.1 protein YkfB -
QFB83_RS02490 (QFB83_02490) 503756..504199 - 444 WP_039025443.1 hypothetical protein -
QFB83_RS02495 (QFB83_02495) 504199..504435 - 237 WP_001115854.1 protein YpjK -
QFB83_RS02500 (QFB83_02500) 504472..505173 - 702 WP_280596648.1 WYL domain-containing protein -
QFB83_RS02505 (QFB83_02505) 505390..506211 - 822 WP_039025441.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12880.79 Da        Isoelectric Point: 9.6548

>T279064 WP_039025449.1 NZ_CP123598:c501620-501279 [Enterobacter cloacae]
MNTLPATTQRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFSDETVIREHINAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAVDILRARQATGLLRQSRNNSVQ

Download         Length: 342 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11859.48 Da        Isoelectric Point: 6.7339

>AT279064 WP_280596645.1 NZ_CP123598:c501958-501641 [Enterobacter cloacae]
MSNITWGLQRAITPCLGARLVQEGNRLHYLADRASITGKFSDAECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7I6XXA8

Antitoxin

Source ID Structure

References