Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 315253..315913 Replicon chromosome
Accession NZ_CP123598
Organism Enterobacter cloacae strain RMCH-M23-N

Toxin (Protein)


Gene name cptA Uniprot ID A0A5E1AGQ2
Locus tag QFB83_RS01575 Protein ID WP_023620447.1
Coordinates 315253..315666 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A5E1AG01
Locus tag QFB83_RS01580 Protein ID WP_013098615.1
Coordinates 315647..315913 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFB83_RS01555 (QFB83_01555) 311246..312979 - 1734 WP_280596520.1 single-stranded-DNA-specific exonuclease RecJ -
QFB83_RS01560 (QFB83_01560) 312985..313698 - 714 WP_013098611.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QFB83_RS01565 (QFB83_01565) 313727..314623 - 897 WP_013098612.1 site-specific tyrosine recombinase XerD -
QFB83_RS01570 (QFB83_01570) 314725..315246 + 522 WP_013098613.1 flavodoxin FldB -
QFB83_RS01575 (QFB83_01575) 315253..315666 - 414 WP_023620447.1 protein YgfX Toxin
QFB83_RS01580 (QFB83_01580) 315647..315913 - 267 WP_013098615.1 FAD assembly factor SdhE Antitoxin
QFB83_RS01585 (QFB83_01585) 316208..317188 + 981 WP_023620448.1 tRNA-modifying protein YgfZ -
QFB83_RS01590 (QFB83_01590) 317298..317957 - 660 WP_003863433.1 hemolysin III family protein -
QFB83_RS01595 (QFB83_01595) 318223..318954 + 732 WP_020687085.1 MurR/RpiR family transcriptional regulator -
QFB83_RS01600 (QFB83_01600) 319070..320503 + 1434 WP_020687084.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16220.21 Da        Isoelectric Point: 10.9554

>T279063 WP_023620447.1 NZ_CP123598:c315666-315253 [Enterobacter cloacae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLSSGMMLRLRQVGGGKCQHLWLAADSMDIAEWRELRRMLLQQQPTQE

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1456

>AT279063 WP_013098615.1 NZ_CP123598:c315913-315647 [Enterobacter cloacae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDEDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E1AGQ2

Antitoxin

Source ID Structure
AlphaFold DB A0A5E1AG01

References