Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 4402056..4402591 Replicon chromosome
Accession NZ_CP123597
Organism Serratia marcescens strain RMCH-M26-N

Toxin (Protein)


Gene name relE Uniprot ID A0A086G6D5
Locus tag QFB82_RS21110 Protein ID WP_033631416.1
Coordinates 4402316..4402591 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A086G6D4
Locus tag QFB82_RS21105 Protein ID WP_033631415.1
Coordinates 4402056..4402316 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFB82_RS21085 (QFB82_21085) 4397380..4398030 + 651 WP_280597786.1 DUF1795 domain-containing protein -
QFB82_RS21090 (QFB82_21090) 4398066..4398671 + 606 WP_033631412.1 glutathione S-transferase -
QFB82_RS21095 (QFB82_21095) 4398741..4400135 + 1395 WP_048326782.1 L-seryl-tRNA(Sec) selenium transferase -
QFB82_RS21100 (QFB82_21100) 4400132..4401973 + 1842 WP_060558044.1 selenocysteine-specific translation elongation factor -
QFB82_RS21105 (QFB82_21105) 4402056..4402316 + 261 WP_033631415.1 ribbon-helix-helix domain-containing protein Antitoxin
QFB82_RS21110 (QFB82_21110) 4402316..4402591 + 276 WP_033631416.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QFB82_RS21115 (QFB82_21115) 4402603..4403514 - 912 WP_033631417.1 LysR family transcriptional regulator -
QFB82_RS21120 (QFB82_21120) 4403636..4404262 + 627 WP_033631418.1 LysE family translocator -
QFB82_RS21125 (QFB82_21125) 4404316..4405563 - 1248 WP_033633516.1 MFS transporter -
QFB82_RS21130 (QFB82_21130) 4405781..4406773 + 993 WP_049278450.1 acyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10548.30 Da        Isoelectric Point: 10.3377

>T279062 WP_033631416.1 NZ_CP123597:4402316-4402591 [Serratia marcescens]
MELKWTSKALSDLARLFEFLALANRTAAANSVKALVAAPKALLDNPRLGERLDEFLPQEVRRILVGRYEIRYQVQPAAIY
VLRIWHTREER

Download         Length: 276 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9712.03 Da        Isoelectric Point: 4.5317

>AT279062 WP_033631415.1 NZ_CP123597:4402056-4402316 [Serratia marcescens]
MNTKVITAHVPLPLAEKVDEMAAKLERSRGWIVKQALTAWLEQEEERRRLTLAALADVEQQNVIDHESVEAWAASLDSDE
PLPVPR

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086G6D5

Antitoxin

Source ID Structure
AlphaFold DB A0A086G6D4

References