Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4360475..4361076 Replicon chromosome
Accession NZ_CP123597
Organism Serratia marcescens strain RMCH-M26-N

Toxin (Protein)


Gene name vapC Uniprot ID A0A0P0Q8I8
Locus tag QFB82_RS20925 Protein ID WP_004933929.1
Coordinates 4360475..4360855 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A086G6A0
Locus tag QFB82_RS20930 Protein ID WP_004933932.1
Coordinates 4360855..4361076 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFB82_RS20900 (QFB82_20900) 4355722..4357002 + 1281 WP_280597780.1 DUF3748 domain-containing protein -
QFB82_RS20905 (QFB82_20905) 4357033..4357380 - 348 WP_004933911.1 YceK/YidQ family lipoprotein -
QFB82_RS20910 (QFB82_20910) 4357689..4358102 + 414 WP_004933919.1 small heat shock chaperone IbpA -
QFB82_RS20915 (QFB82_20915) 4358210..4358638 + 429 WP_004933922.1 small heat shock chaperone IbpB -
QFB82_RS20920 (QFB82_20920) 4358806..4360464 + 1659 WP_015376152.1 putative transporter -
QFB82_RS20925 (QFB82_20925) 4360475..4360855 - 381 WP_004933929.1 type II toxin-antitoxin system VapC family toxin Toxin
QFB82_RS20930 (QFB82_20930) 4360855..4361076 - 222 WP_004933932.1 ribbon-helix-helix domain-containing protein Antitoxin
QFB82_RS20935 (QFB82_20935) 4361151..4362401 - 1251 WP_280597781.1 valine--pyruvate transaminase -
QFB82_RS20940 (QFB82_20940) 4362537..4364600 - 2064 WP_280597782.1 alpha-amylase -
QFB82_RS20945 (QFB82_20945) 4364796..4364948 + 153 WP_162837994.1 hypothetical protein -
QFB82_RS20950 (QFB82_20950) 4364950..4365927 - 978 WP_033631399.1 glyoxylate/hydroxypyruvate reductase GhrB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-102)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14173.48 Da        Isoelectric Point: 7.3170

>T279061 WP_004933929.1 NZ_CP123597:c4360855-4360475 [Serratia marcescens]
MVAQRALFDTNILIDYLNGIPQAKDVLTEYHTNPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIIWATAQVGFRTLISRNPKDFGTDNGVLMPYRL

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8593.53 Da        Isoelectric Point: 4.4791

>AT279061 WP_004933932.1 NZ_CP123597:c4361076-4360855 [Serratia marcescens]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLTENHVEDPSNAFGLWSGAMGDGVDYENRQREEWE

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P0Q8I8

Antitoxin

Source ID Structure
AlphaFold DB A0A086G6A0

References