Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3019818..3020474 Replicon chromosome
Accession NZ_CP123597
Organism Serratia marcescens strain RMCH-M26-N

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QFB82_RS14650 Protein ID WP_049239890.1
Coordinates 3019818..3020207 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QFB82_RS14655 Protein ID WP_164096894.1
Coordinates 3020211..3020474 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFB82_RS14635 (QFB82_14635) 3016285..3017715 + 1431 WP_213929626.1 multidrug transporter subunit MdtD -
QFB82_RS14640 (QFB82_14640) 3017712..3019094 + 1383 WP_016926705.1 two-component system sensor histidine kinase BaeS -
QFB82_RS14645 (QFB82_14645) 3019094..3019810 + 717 WP_004941568.1 two-component system response regulator BaeR -
QFB82_RS14650 (QFB82_14650) 3019818..3020207 - 390 WP_049239890.1 type II toxin-antitoxin system VapC family toxin Toxin
QFB82_RS14655 (QFB82_14655) 3020211..3020474 - 264 WP_164096894.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
QFB82_RS14660 (QFB82_14660) 3020812..3021150 + 339 WP_004941561.1 YegP family protein -
QFB82_RS14665 (QFB82_14665) 3021329..3022681 + 1353 WP_004941558.1 tRNA 5-hydroxyuridine modification protein YegQ -
QFB82_RS14670 (QFB82_14670) 3023149..3024054 + 906 WP_015378742.1 lipid kinase YegS -
QFB82_RS14675 (QFB82_14675) 3024315..3025364 + 1050 WP_015378749.1 class I fructose-bisphosphate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14425.66 Da        Isoelectric Point: 8.4983

>T279058 WP_049239890.1 NZ_CP123597:c3020207-3019818 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELRYGVAKRRNKALQNMVEAFLAAVTVYAWDSEAARCYGEM
RANMERKGKIMGAMDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10043.27 Da        Isoelectric Point: 4.6677

>AT279058 WP_164096894.1 NZ_CP123597:c3020474-3020211 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADH
DPFSEEE

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References