Detailed information of TA system TA027905

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-VagC
• Location: 1559320..1559994
• Replicon: chromosome
• Accession: NC_018012
• Organism: Thiocystis violascens DSM 198

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: I3Y8W6
• Locus tag: THIVI_RS06910
• Protein ID: WP_014777908.1
• Coordinates: 1559578..1559994 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: I3Y8W5
• Locus tag: THIVI_RS06905
• Protein ID: WP_014777907.1
• Coordinates: 1559320..1559562 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
THIVI_RS06885	1555102..1556064	+	963	WP_014777902.1	2-hydroxyacid dehydrogenase	-
THIVI_RS06890	1556256..1556726	-	471	WP_014777903.1	Hsp20 family protein	-
THIVI_RS24530	1557216..1557362	-	147	WP_014777905.1	hypothetical protein	-
THIVI_RS06895	1557402..1557953	-	552	WP_041446867.1	DUF3987 domain-containing protein	-
THIVI_RS23460	1557934..1558323	-	390	Protein_1401	DUF3987 domain-containing protein	-
THIVI_RS23465	1558476..1558676	-	201	WP_157174589.1	AlpA family phage regulatory protein	-
THIVI_RS25065	1558633..1558878	+	246	WP_014777906.1	hypothetical protein	-
THIVI_RS06905	1559320..1559562	+	243	WP_014777907.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
THIVI_RS06910	1559578..1559994	+	417	WP_014777908.1	type II toxin-antitoxin system VapC family toxin	Toxin
THIVI_RS06915	1560189..1561448	-	1260	WP_014777909.1	hypothetical protein	-
THIVI_RS06920	1561491..1561685	-	195	WP_014777910.1	hypothetical protein	-
THIVI_RS23470	1561796..1561912	-	117	WP_014777911.1	DUF1810 family protein	-
THIVI_RS06925	1561983..1563068	-	1086	WP_157174387.1	App1 family protein	-
THIVI_RS06930	1563184..1563786	-	603	WP_014777914.1	hypothetical protein	-
THIVI_RS06935	1563839..1564108	-	270	WP_014777915.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-126)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 14922.29 Da
• Isoelectric Point: 5.7223

>T27905 WP_014777908.1 NC_018012:1559578-1559994 [Thiocystis violascens DSM 198]
MSALRYLLDTNILSALIREPQGPVATLLSRRGHDRVCTSLIVAAELRFGALKRGSPVLLGKVSDLLASMPVLPLEAGVDE
AYARVRLALEQAGTLIGPNDLLIAAHALDQDLTLVTDNADEFSRVPALRVENWLATQR

Nucleotide

• Length: 417 bp

>T27905 NC_018012:1559578-1559994 [Thiocystis violascens DSM 198]
ATGTCCGCGCTGCGCTATCTCCTCGACACCAACATCCTTTCGGCGCTGATCCGCGAGCCGCAAGGCCCGGTCGCAACACT
CCTGAGCCGCCGTGGCCACGATCGGGTGTGCACCAGCCTCATCGTCGCGGCCGAGCTGCGCTTCGGCGCGCTCAAGCGCG
GTTCGCCCGTCTTGCTCGGCAAAGTCTCGGACCTGCTCGCGTCCATGCCGGTCTTGCCGCTCGAGGCCGGTGTCGATGAA
GCCTACGCGAGGGTACGCCTTGCCCTGGAGCAAGCGGGAACGCTGATCGGCCCCAACGATCTGCTGATCGCCGCCCATGC
CCTGGATCAGGATCTCACGCTCGTGACGGACAATGCGGACGAATTCAGCCGGGTACCCGCGCTGCGGGTCGAGAATTGGC
TCGCCACCCAACGCTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9177.50 Da
• Isoelectric Point: 4.8362

>AT27905 WP_014777907.1 NC_018012:1559320-1559562 [Thiocystis violascens DSM 198]
MQSERHVRLFRNGRNQALRIPRDLELDADEAVIRRDGERLIIEPVKRRADLATLLAGWKPLDETLPDIDAGLPPLDDIQL

Nucleotide

• Length: 243 bp

>AT27905 NC_018012:1559320-1559562 [Thiocystis violascens DSM 198]
ATGCAATCGGAACGCCATGTTCGCCTCTTTCGCAATGGTCGCAATCAAGCGCTGCGGATCCCGCGCGACTTGGAGCTGGA
TGCCGACGAGGCGGTGATTCGCCGTGACGGCGAGCGGCTGATCATCGAGCCTGTCAAGCGCCGAGCCGATCTCGCGACGC
TGCTTGCTGGCTGGAAGCCCCTCGATGAGACCCTGCCGGATATCGACGCAGGGCTCCCGCCACTCGACGATATCCAACTC
TAG

Structures

Toxin

• AlphaFold DB: I3Y8W6

Antitoxin

• AlphaFold DB: I3Y8W5