Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 2502282..2502918 Replicon chromosome
Accession NZ_CP123578
Organism Priestia megaterium strain HyangYak-01

Toxin (Protein)


Gene name mazF Uniprot ID D5DWT4
Locus tag QEP22_RS13515 Protein ID WP_013055004.1
Coordinates 2502568..2502918 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID D5DWT3
Locus tag QEP22_RS13510 Protein ID WP_013055003.1
Coordinates 2502282..2502563 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEP22_RS13485 2497648..2498619 + 972 WP_280560705.1 UV DNA damage repair endonuclease UvsE -
QEP22_RS13490 2498628..2499230 - 603 WP_043977820.1 rhomboid family intramembrane serine protease -
QEP22_RS13495 2499295..2499660 + 366 WP_043977839.1 holo-ACP synthase -
QEP22_RS13500 2499719..2500777 + 1059 WP_043977822.1 outer membrane lipoprotein carrier protein LolA -
QEP22_RS13505 2500891..2502081 + 1191 WP_280560706.1 alanine racemase -
QEP22_RS13510 2502282..2502563 + 282 WP_013055003.1 hypothetical protein Antitoxin
QEP22_RS13515 2502568..2502918 + 351 WP_013055004.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QEP22_RS13520 2503076..2503912 + 837 WP_013055005.1 RsbT co-antagonist protein RsbRA -
QEP22_RS13525 2503915..2504271 + 357 WP_013055006.1 STAS domain-containing protein -
QEP22_RS13530 2504275..2504676 + 402 WP_013055007.1 anti-sigma regulatory factor -
QEP22_RS13535 2504690..2505700 + 1011 WP_013055008.1 PP2C family protein-serine/threonine phosphatase -
QEP22_RS13540 2505760..2506092 + 333 WP_013055009.1 anti-sigma factor antagonist -
QEP22_RS13545 2506089..2506574 + 486 WP_013055010.1 anti-sigma B factor RsbW -
QEP22_RS13550 2506540..2507334 + 795 WP_013055011.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12991.96 Da        Isoelectric Point: 4.8781

>T279048 WP_013055004.1 NZ_CP123578:2502568-2502918 [Priestia megaterium]
MVVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDRVDEALQISVGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10691.22 Da        Isoelectric Point: 8.5339

>AT279048 WP_013055003.1 NZ_CP123578:2502282-2502563 [Priestia megaterium]
VSEASATTEILVRLPKNLVSELDLMVKQENGNRSDFIHQATKLYLRERKKRHIRESMRRGYMEMAKINLNIASEAFLAEY
EADHTVDRLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0B6AMB9

References