Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 61568..62204 Replicon plasmid paNv_UK3
Accession NZ_CP123564
Organism Arsenophonus nasoniae strain aNv_UK

Toxin (Protein)


Gene name vapC Uniprot ID A0A4P7L2E3
Locus tag QE193_RS21965 Protein ID WP_026823396.1
Coordinates 61800..62204 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A4P7L1M6
Locus tag QE193_RS21960 Protein ID WP_026823397.1
Coordinates 61568..61807 (+) Length 80 a.a.

Genomic Context

QE193_RS21950QE193_RS21955QE193_RS21960QE193_RS21965QE193_RS21970QE193_RS21975QE193_RS21980QE193_RS21985QE193_RS21990QE193_RS21995QE193_RS22000QE193_RS21935QE193_RS21940QE193_RS21945
Location: 60371..61060 (690 bp)
Type: Others
Protein ID: WP_026823399.1
Location: 61078..61461 (384 bp)
Type: Others
Protein ID: WP_026823398.1
Location: 61568..61807 (240 bp)
Type: Antitoxin
Protein ID: WP_026823397.1
Location: 61800..62204 (405 bp)
Type: Toxin
Protein ID: WP_026823396.1
Location: 62649..63614 (966 bp)
Type: Others
Protein ID: WP_051297076.1
Location: 63611..63769 (159 bp)
Type: Others
Protein ID: WP_155846998.1
Location: 63819..63995 (177 bp)
Type: Others
Protein ID: WP_167876777.1
Location: 63997..64431 (435 bp)
Type: Others
Protein ID: WP_026823394.1
Location: 64480..65235 (756 bp)
Type: Others
Protein ID: WP_135678964.1
Location: 65238..65831 (594 bp)
Type: Others
Protein ID: WP_026823392.1
Location: 65809..66177 (369 bp)
Type: Others
Protein ID: WP_026823391.1
Location: 56970..57731 (762 bp)
Type: Others
Protein ID: WP_135677409.1
Location: 57718..58772 (1055 bp)
Type: Others
Protein ID: Protein_57
Location: 58762..59919 (1158 bp)
Type: Others
Protein ID: Protein_58
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
QE193_RS21935 (QE193_21945)56970..57731-762WP_135677409.1IS21-like element helper ATPase IstB-
QE193_RS21940 (QE193_21950)57718..58772-1055Protein_57IS21 family transposase-
QE193_RS21945 (QE193_21955)58762..59919-1158Protein_58IS3 family transposase-
QE193_RS21950 (QE193_21960)60371..61060+690WP_026823399.1hypothetical protein-
QE193_RS21955 (QE193_21965)61078..61461+384WP_026823398.1hypothetical protein-
QE193_RS21960 (QE193_21970)61568..61807+240WP_026823397.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
QE193_RS21965 (QE193_21975)61800..62204+405WP_026823396.1type II toxin-antitoxin system VapC family toxinToxin
QE193_RS21970 (QE193_21980)62649..63614+966WP_051297076.1tyrosine-type recombinase/integrase-
QE193_RS21975 (QE193_21985)63611..63769+159WP_155846998.1hypothetical protein-
QE193_RS21980 (QE193_21990)63819..63995+177WP_167876777.1hypothetical protein-
QE193_RS21985 (QE193_21995)63997..64431+435WP_026823394.1hypothetical protein-
QE193_RS21990 (QE193_22000)64480..65235+756WP_135678964.1signal peptidase I-
QE193_RS21995 (QE193_22005)65238..65831+594WP_026823392.1hypothetical protein-
QE193_RS22000 (QE193_22010)65809..66177+369WP_026823391.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..135571135571


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15217.49 Da        Isoelectric Point: 8.5036

>T279044 WP_026823396.1 NZ_CP123564:61800-62204 [Arsenophonus nasoniae]
MIKYLLDTNIVIFTIKRKPVSLLPKFNQHTNQLAISAITFAELIFGAEKSMNSAKNLATVNDFVSRLTVLPYDEQAAFHY
GDIKANFEKKEKPIGDNDLHIAAHARSKGLVVVTNNTREFERVEGLRIEDWTQL

Download         Length: 405 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9195.27 Da        Isoelectric Point: 4.7420

>AT279044 WP_026823397.1 NZ_CP123564:61568-61807 [Arsenophonus nasoniae]
MIQQGKVFMSNRTQNVRLPADTRFPDDVKDVIVRVKGKERIISPVQNAWDSFFLSEQSVTDDFLSNRTEQITSERESFD

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A4P7L2E3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A4P7L1M6

References