Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-pasA/RelE-HTH
Location 23208..23682 Replicon plasmid paNv_UK3
Accession NZ_CP123564
Organism Arsenophonus nasoniae strain aNv_UK

Toxin (Protein)


Gene name relE Uniprot ID A0A4P7L6N8
Locus tag QE193_RS21785 Protein ID WP_026823134.1
Coordinates 23416..23682 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A4P7L1P3
Locus tag QE193_RS21780 Protein ID WP_026823135.1
Coordinates 23208..23432 (+) Length 75 a.a.

Genomic Context

QE193_RS21760QE193_RS21780QE193_RS21785QE193_RS21800QE193_RS21805QE193_RS21810QE193_RS21755QE193_RS21765QE193_RS21770QE193_RS21775QE193_RS21790QE193_RS21795
Location: 20372..20683 (312 bp)
Type: Others
Protein ID: WP_167876782.1
Location: 23208..23432 (225 bp)
Type: Antitoxin
Protein ID: WP_026823135.1
Location: 23416..23682 (267 bp)
Type: Toxin
Protein ID: WP_026823134.1
Location: 26060..26518 (459 bp)
Type: Others
Protein ID: WP_248604879.1
Location: 26528..27463 (936 bp)
Type: Others
Protein ID: WP_246067601.1
Location: 27521..28525 (1005 bp)
Type: Others
Protein ID: WP_280622596.1
Location: 18615..19559 (945 bp)
Type: Others
Protein ID: WP_135679022.1
Location: 20713..21996 (1284 bp)
Type: Others
Protein ID: WP_051297045.1
Location: 22407..22682 (276 bp)
Type: Others
Protein ID: WP_026823137.1
Location: 22679..22861 (183 bp)
Type: Others
Protein ID: WP_026823136.1
Location: 23803..24420 (618 bp)
Type: Others
Protein ID: WP_081700663.1
Location: 24425..25408 (984 bp)
Type: Others
Protein ID: WP_026823133.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
QE193_RS21755 (QE193_21765)18615..19559-945WP_135679022.1replication initiator protein A-
QE193_RS21760 (QE193_21770)20372..20683+312WP_167876782.1colicin E1 family microcin immunity protein-
QE193_RS21765 (QE193_21775)20713..21996-1284WP_051297045.1colicin-like pore-forming protein-
QE193_RS21770 (QE193_21780)22407..22682-276WP_026823137.1response regulator transcription factor-
QE193_RS21775 (QE193_21785)22679..22861-183WP_026823136.1hypothetical protein-
QE193_RS21780 (QE193_21790)23208..23432+225WP_026823135.1DUF6290 family proteinAntitoxin
QE193_RS21785 (QE193_21795)23416..23682+267WP_026823134.1type II toxin-antitoxin system RelE/ParE family toxinToxin
QE193_RS21790 (QE193_21800)23803..24420-618WP_081700663.1plasmid partitioning/stability family protein-
QE193_RS21795 (QE193_21805)24425..25408-984WP_026823133.1plasmid segregation protein ParM-
QE193_RS21800 (QE193_21810)26060..26518+459WP_248604879.1hypothetical protein-
QE193_RS21805 (QE193_21815)26528..27463+936WP_246067601.1IS91 family transposase-
QE193_RS21810 (QE193_21820)27521..28525+1005WP_280622596.1IS21 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..135571135571


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Relaxosome protein TraY

(4-44)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10406.12 Da        Isoelectric Point: 9.3777

>T279043 WP_026823134.1 NZ_CP123564:23416-23682 [Arsenophonus nasoniae]
MVWKIKYADSALKSLKKMDRQNAKRIVDYLDKRIASSDDPRIFGKSLKGDLGEFWRYRIGDYRVICEILDEELIILAAII
GHRREVYE

Download         Length: 267 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8474.56 Da        Isoelectric Point: 5.6993

>AT279043 WP_026823135.1 NZ_CP123564:23208-23432 [Arsenophonus nasoniae]
MLAIRLPDEIENRLDNLAKRTGRTKTFYAREAILTHLEDLEDYYLAASVVARVRKGQDTVHSSEDVRKSLGLED

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A4P7L6N8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A4P7L1P3

References