Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2881526..2882154 Replicon chromosome
Accession NZ_CP123561
Organism Arsenophonus nasoniae strain aNv_UK

Toxin (Protein)


Gene name Hha Uniprot ID D2TWD5
Locus tag QE193_RS14970 Protein ID WP_026821483.1
Coordinates 2881951..2882154 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A4P7KX12
Locus tag QE193_RS14965 Protein ID WP_026821484.1
Coordinates 2881526..2881894 (+) Length 123 a.a.

Genomic Context

QE193_RS14955QE193_RS14960QE193_RS14965QE193_RS14970QE193_RS14980QE193_RS14985
Location: 2876680..2877843 (1164 bp)
Type: Others
Protein ID: WP_026821486.1
Location: 2877886..2881005 (3120 bp)
Type: Others
Protein ID: WP_026821485.1
Location: 2881526..2881894 (369 bp)
Type: Antitoxin
Protein ID: WP_026821484.1
Location: 2881951..2882154 (204 bp)
Type: Toxin
Protein ID: WP_026821483.1
Location: 2882952..2884732 (1781 bp)
Type: Others
Protein ID: Protein_2916
Location: 2884725..2886471 (1747 bp)
Type: Others
Protein ID: Protein_2917
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
QE193_RS14955 (QE193_14960)2876680..2877843+1164WP_026821486.1efflux RND transporter periplasmic adaptor subunit-
QE193_RS14960 (QE193_14965)2877886..2881005+3120WP_026821485.1efflux RND transporter permease subunit-
QE193_RS14965 (QE193_14970)2881526..2881894+369WP_026821484.1Hha toxicity modulator TomBAntitoxin
QE193_RS14970 (QE193_14975)2881951..2882154+204WP_026821483.1HHA domain-containing proteinToxin
QE193_RS14980 (QE193_14985)2882952..2884732-1781Protein_2916SmdB family multidrug efflux ABC transporter permease/ATP-binding protein-
QE193_RS14985 (QE193_14990)2884725..2886471-1747Protein_2917SmdA family multidrug ABC transporter permease/ATP-binding protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8133.45 Da        Isoelectric Point: 6.9767

>T279040 WP_026821483.1 NZ_CP123561:2881951-2882154 [Arsenophonus nasoniae]
MTKIDYLMRLRKCTTIETLERVIEKNKYELSEDELELFYSAADHRLAELTMNKLYDKIPSSVWKYVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14453.41 Da        Isoelectric Point: 5.1197

>AT279040 WP_026821484.1 NZ_CP123561:2881526-2881894 [Arsenophonus nasoniae]
MDEYSPRSYDILVLKYLCDALHRDAMLTLHRTKTHWKNDLGSDQNVKFNVLIDHITDFIGQFKLKYPNNVNLFIFIDEYL
DETYNLFGKPVMSLTDISDWQKMNEHLSEILTNDIKYSLSNT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBD2TWD5

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A4P7KX12

References