Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2881526..2882154 Replicon chromosome
Accession NZ_CP123561
Organism Arsenophonus nasoniae strain aNv_UK

Toxin (Protein)


Gene name Hha Uniprot ID D2TWD5
Locus tag QE193_RS14970 Protein ID WP_026821483.1
Coordinates 2881951..2882154 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A4P7KX12
Locus tag QE193_RS14965 Protein ID WP_026821484.1
Coordinates 2881526..2881894 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QE193_RS14955 (QE193_14960) 2876680..2877843 + 1164 WP_026821486.1 efflux RND transporter periplasmic adaptor subunit -
QE193_RS14960 (QE193_14965) 2877886..2881005 + 3120 WP_026821485.1 efflux RND transporter permease subunit -
QE193_RS14965 (QE193_14970) 2881526..2881894 + 369 WP_026821484.1 Hha toxicity modulator TomB Antitoxin
QE193_RS14970 (QE193_14975) 2881951..2882154 + 204 WP_026821483.1 HHA domain-containing protein Toxin
QE193_RS14980 (QE193_14985) 2882952..2884732 - 1781 Protein_2916 SmdB family multidrug efflux ABC transporter permease/ATP-binding protein -
QE193_RS14985 (QE193_14990) 2884725..2886471 - 1747 Protein_2917 SmdA family multidrug ABC transporter permease/ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8133.45 Da        Isoelectric Point: 6.9767

>T279040 WP_026821483.1 NZ_CP123561:2881951-2882154 [Arsenophonus nasoniae]
MTKIDYLMRLRKCTTIETLERVIEKNKYELSEDELELFYSAADHRLAELTMNKLYDKIPSSVWKYVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14453.41 Da        Isoelectric Point: 5.1197

>AT279040 WP_026821484.1 NZ_CP123561:2881526-2881894 [Arsenophonus nasoniae]
MDEYSPRSYDILVLKYLCDALHRDAMLTLHRTKTHWKNDLGSDQNVKFNVLIDHITDFIGQFKLKYPNNVNLFIFIDEYL
DETYNLFGKPVMSLTDISDWQKMNEHLSEILTNDIKYSLSNT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D2TWD5

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7KX12

References