279032

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2880534..2881162 Replicon chromosome
Accession NZ_CP123544
Organism Arsenophonus nasoniae strain aNv_CH

Toxin (Protein)


Gene name Hha Uniprot ID D2TWD5
Locus tag QE197_RS15060 Protein ID WP_026821483.1
Coordinates 2880959..2881162 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A4P7KX12
Locus tag QE197_RS15055 Protein ID WP_026821484.1
Coordinates 2880534..2880902 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QE197_RS15045 (QE197_15050) 2875688..2876851 + 1164 WP_026821486.1 efflux RND transporter periplasmic adaptor subunit -
QE197_RS15050 (QE197_15055) 2876894..2880013 + 3120 WP_026821485.1 efflux RND transporter permease subunit -
QE197_RS15055 (QE197_15060) 2880534..2880902 + 369 WP_026821484.1 Hha toxicity modulator TomB Antitoxin
QE197_RS15060 (QE197_15065) 2880959..2881162 + 204 WP_026821483.1 HHA domain-containing protein Toxin
QE197_RS15070 (QE197_15075) 2881960..2883740 - 1781 Protein_2934 SmdB family multidrug efflux ABC transporter permease/ATP-binding protein -
QE197_RS15075 (QE197_15080) 2883733..2885479 - 1747 Protein_2935 SmdA family multidrug ABC transporter permease/ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8133.45 Da        Isoelectric Point: 6.9767

>T279032 WP_026821483.1 NZ_CP123544:2880959-2881162 [Arsenophonus nasoniae]
MTKIDYLMRLRKCTTIETLERVIEKNKYELSEDELELFYSAADHRLAELTMNKLYDKIPSSVWKYVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14453.41 Da        Isoelectric Point: 5.1197

>AT279032 WP_026821484.1 NZ_CP123544:2880534-2880902 [Arsenophonus nasoniae]
MDEYSPRSYDILVLKYLCDALHRDAMLTLHRTKTHWKNDLGSDQNVKFNVLIDHITDFIGQFKLKYPNNVNLFIFIDEYL
DETYNLFGKPVMSLTDISDWQKMNEHLSEILTNDIKYSLSNT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D2TWD5

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7KX12

References