Detailed information of TA system TA027903

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/Txe-RelB
• Location: 209236..209756
• Replicon: chromosome
• Accession: NC_018011
• Organism: Alistipes finegoldii DSM 17242

Toxin (Protein)

• Gene name: relE
• Uniprot ID: I3YHX8
• Locus tag: ALFI_RS00960
• Protein ID: WP_014774404.1
• Coordinates: 209487..209756 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: I3YHX7
• Locus tag: ALFI_RS00955
• Protein ID: WP_014774403.1
• Coordinates: 209236..209496 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ALFI_RS00925	206062..206427	+	366	WP_014774396.1	DUF2693 domain-containing protein	-
ALFI_RS00930	207482..207772	+	291	WP_014774398.1	hypothetical protein	-
ALFI_RS00940	207986..208258	+	273	WP_014774400.1	hypothetical protein	-
ALFI_RS00945	208333..208662	+	330	WP_155835617.1	single-stranded DNA-binding protein	-
ALFI_RS00950	208746..208946	+	201	WP_014774402.1	hypothetical protein	-
ALFI_RS00955	209236..209496	+	261	WP_014774403.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
ALFI_RS00960	209487..209756	+	270	WP_014774404.1	Txe/YoeB family addiction module toxin	Toxin
ALFI_RS00965	210356..211345	+	990	WP_014774405.1	DUF1738 domain-containing protein	-
ALFI_RS00970	212131..212463	+	333	WP_014774406.1	hypothetical protein	-
ALFI_RS00975	212501..213046	+	546	WP_014774407.1	hypothetical protein	-
ALFI_RS00980	213117..213671	+	555	WP_009597036.1	hypothetical protein	-
ALFI_RS00985	213688..214215	+	528	WP_014774408.1	hypothetical protein	-
ALFI_RS00990	214202..214423	+	222	WP_014774409.1	hypothetical protein	-
ALFI_RS00995	214461..214688	+	228	WP_014774410.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10355.95 Da
• Isoelectric Point: 8.4573

>T27903 WP_014774404.1 NC_018011:209487-209756 [Alistipes finegoldii DSM 17242]
MEIVFSEQAQADIAFWKKSGNKAIMNRISALLADIAEHPFTGIGKPEPLKYDLAGKWSRRINTEHRIVYSVHDEMIEVYI
LSMRYHYSK

Nucleotide

• Length: 270 bp

>T27903 NC_018011:209487-209756 [Alistipes finegoldii DSM 17242]
ATGGAAATAGTCTTTTCGGAACAAGCGCAGGCGGACATCGCTTTTTGGAAGAAAAGCGGCAACAAGGCGATTATGAATCG
TATATCCGCATTACTGGCGGATATAGCGGAACATCCGTTCACCGGTATCGGTAAGCCAGAACCCCTGAAGTATGATCTGG
CCGGGAAGTGGTCTCGGCGTATCAATACTGAACATCGCATCGTTTACTCGGTGCACGATGAAATGATCGAGGTCTATATC
CTCTCGATGCGTTATCATTACAGTAAGTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9720.02 Da
• Isoelectric Point: 4.8411

>AT27903 WP_014774403.1 NC_018011:209236-209496 [Alistipes finegoldii DSM 17242]
MRTANYSDLRQNLKTYIDSVIEDSDTVIINRGGGAGVVLMSLDEYNSIKETEYLMKSPENVKRIKAAEQEIRDGKGKVIA
PEDIWK

Nucleotide

• Length: 261 bp

>AT27903 NC_018011:209236-209496 [Alistipes finegoldii DSM 17242]
ATGAGAACAGCAAACTATTCCGATTTAAGGCAGAATCTCAAAACCTATATAGATTCTGTTATCGAGGATTCGGATACGGT
TATCATTAACCGCGGCGGGGGAGCCGGGGTCGTGTTGATGTCTTTGGATGAATATAACTCCATCAAGGAAACCGAGTATC
TTATGAAATCCCCCGAGAATGTGAAGCGTATCAAAGCTGCCGAGCAGGAGATCCGCGACGGCAAAGGAAAGGTTATCGCT
CCTGAAGATATATGGAAATAG

Structures

Toxin

• AlphaFold DB: I3YHX8

Antitoxin

• AlphaFold DB: I3YHX7