Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 53192..53828 Replicon plasmid paNv_CAN3
Accession NZ_CP123526
Organism Arsenophonus nasoniae strain aNv_CAN

Toxin (Protein)


Gene name vapC Uniprot ID A0A4P7L2E3
Locus tag QE258_RS23605 Protein ID WP_026823396.1
Coordinates 53192..53596 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A4P7L1M6
Locus tag QE258_RS23610 Protein ID WP_026823397.1
Coordinates 53589..53828 (-) Length 80 a.a.

Genomic Context

QE258_RS23625QE258_RS23630QE258_RS23635QE258_RS23570QE258_RS23575QE258_RS23580QE258_RS23585QE258_RS23590QE258_RS23595QE258_RS23600QE258_RS23605QE258_RS23610QE258_RS23615QE258_RS23620
Location: 55477..56636 (1160 bp)
Type: Others
Protein ID: WP_135677411.1
Location: 56626..57681 (1056 bp)
Type: Others
Protein ID: WP_135678962.1
Location: 57668..58429 (762 bp)
Type: Others
Protein ID: WP_135677409.1
Location: 49219..49587 (369 bp)
Type: Others
Protein ID: WP_026823391.1
Location: 49565..50158 (594 bp)
Type: Others
Protein ID: WP_026823392.1
Location: 50161..50916 (756 bp)
Type: Others
Protein ID: WP_135678964.1
Location: 50965..51399 (435 bp)
Type: Others
Protein ID: WP_026823394.1
Location: 51401..51577 (177 bp)
Type: Others
Protein ID: WP_167876777.1
Location: 51627..51785 (159 bp)
Type: Others
Protein ID: WP_155846998.1
Location: 51782..52747 (966 bp)
Type: Others
Protein ID: WP_051297076.1
Location: 53192..53596 (405 bp)
Type: Toxin
Protein ID: WP_026823396.1
Location: 53589..53828 (240 bp)
Type: Antitoxin
Protein ID: WP_026823397.1
Location: 53935..54318 (384 bp)
Type: Others
Protein ID: WP_026823398.1
Location: 54336..55025 (690 bp)
Type: Others
Protein ID: WP_026823399.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
QE258_RS23570 (QE258_23580)49219..49587-369WP_026823391.1hypothetical protein-
QE258_RS23575 (QE258_23585)49565..50158-594WP_026823392.1hypothetical protein-
QE258_RS23580 (QE258_23590)50161..50916-756WP_135678964.1signal peptidase I-
QE258_RS23585 (QE258_23595)50965..51399-435WP_026823394.1hypothetical protein-
QE258_RS23590 (QE258_23600)51401..51577-177WP_167876777.1hypothetical protein-
QE258_RS23595 (QE258_23605)51627..51785-159WP_155846998.1hypothetical protein-
QE258_RS23600 (QE258_23610)51782..52747-966WP_051297076.1tyrosine-type recombinase/integrase-
QE258_RS23605 (QE258_23615)53192..53596-405WP_026823396.1type II toxin-antitoxin system VapC family toxinToxin
QE258_RS23610 (QE258_23620)53589..53828-240WP_026823397.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
QE258_RS23615 (QE258_23625)53935..54318-384WP_026823398.1hypothetical protein-
QE258_RS23620 (QE258_23630)54336..55025-690WP_026823399.1hypothetical protein-
QE258_RS23625 (QE258_23635)55477..56636+1160WP_135677411.1IS3 family transposase-
QE258_RS23630 (QE258_23640)56626..57681+1056WP_135678962.1IS21 family transposase-
QE258_RS23635 (QE258_23645)57668..58429+762WP_135677409.1IS21-like element helper ATPase IstB-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..140345140345
-flankIS/Tn--55477..55791314


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15217.49 Da        Isoelectric Point: 8.5036

>T279027 WP_026823396.1 NZ_CP123526:c53596-53192 [Arsenophonus nasoniae]
MIKYLLDTNIVIFTIKRKPVSLLPKFNQHTNQLAISAITFAELIFGAEKSMNSAKNLATVNDFVSRLTVLPYDEQAAFHY
GDIKANFEKKEKPIGDNDLHIAAHARSKGLVVVTNNTREFERVEGLRIEDWTQL

Download         Length: 405 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9195.27 Da        Isoelectric Point: 4.7420

>AT279027 WP_026823397.1 NZ_CP123526:c53828-53589 [Arsenophonus nasoniae]
MIQQGKVFMSNRTQNVRLPADTRFPDDVKDVIVRVKGKERIISPVQNAWDSFFLSEQSVTDDFLSNRTEQITSERESFD

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A4P7L2E3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A4P7L1M6

References