Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3068558..3069186 Replicon chromosome
Accession NZ_CP123523
Organism Arsenophonus nasoniae strain aNv_CAN

Toxin (Protein)


Gene name Hha Uniprot ID D2TWD5
Locus tag QE258_RS16425 Protein ID WP_026821483.1
Coordinates 3068983..3069186 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A4P7KX12
Locus tag QE258_RS16420 Protein ID WP_026821484.1
Coordinates 3068558..3068926 (+) Length 123 a.a.

Genomic Context

QE258_RS16410QE258_RS16415QE258_RS16420QE258_RS16425QE258_RS16435QE258_RS16440
Location: 3063713..3064876 (1164 bp)
Type: Others
Protein ID: WP_026821486.1
Location: 3064919..3068038 (3120 bp)
Type: Others
Protein ID: WP_026821485.1
Location: 3068558..3068926 (369 bp)
Type: Antitoxin
Protein ID: WP_026821484.1
Location: 3068983..3069186 (204 bp)
Type: Toxin
Protein ID: WP_026821483.1
Location: 3069984..3071764 (1781 bp)
Type: Others
Protein ID: Protein_3207
Location: 3071757..3073503 (1747 bp)
Type: Others
Protein ID: Protein_3208
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
QE258_RS16410 (QE258_16415)3063713..3064876+1164WP_026821486.1efflux RND transporter periplasmic adaptor subunit-
QE258_RS16415 (QE258_16420)3064919..3068038+3120WP_026821485.1efflux RND transporter permease subunit-
QE258_RS16420 (QE258_16425)3068558..3068926+369WP_026821484.1Hha toxicity modulator TomBAntitoxin
QE258_RS16425 (QE258_16430)3068983..3069186+204WP_026821483.1HHA domain-containing proteinToxin
QE258_RS16435 (QE258_16440)3069984..3071764-1781Protein_3207SmdB family multidrug efflux ABC transporter permease/ATP-binding protein-
QE258_RS16440 (QE258_16445)3071757..3073503-1747Protein_3208SmdA family multidrug ABC transporter permease/ATP-binding protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8133.45 Da        Isoelectric Point: 6.9767

>T279024 WP_026821483.1 NZ_CP123523:3068983-3069186 [Arsenophonus nasoniae]
MTKIDYLMRLRKCTTIETLERVIEKNKYELSEDELELFYSAADHRLAELTMNKLYDKIPSSVWKYVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14453.41 Da        Isoelectric Point: 5.1197

>AT279024 WP_026821484.1 NZ_CP123523:3068558-3068926 [Arsenophonus nasoniae]
MDEYSPRSYDILVLKYLCDALHRDAMLTLHRTKTHWKNDLGSDQNVKFNVLIDHITDFIGQFKLKYPNNVNLFIFIDEYL
DETYNLFGKPVMSLTDISDWQKMNEHLSEILTNDIKYSLSNT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBD2TWD5

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A4P7KX12

References