Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1691049..1692688 Replicon chromosome
Accession NZ_CP123504
Organism Arsenophonus nasoniae strain aPv

Toxin (Protein)


Gene name HipA3 Uniprot ID -
Locus tag QE210_RS08230 Protein ID WP_280626128.1
Coordinates 1691049..1692359 (-) Length 437 a.a.

Antitoxin (Protein)


Gene name HipB3 Uniprot ID -
Locus tag QE210_RS08235 Protein ID WP_026823614.1
Coordinates 1692359..1692688 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QE210_RS08200 (QE210_08170) 1686099..1687271 - 1173 WP_026823611.1 hypothetical protein -
QE210_RS08205 (QE210_08175) 1687440..1687850 - 411 WP_280626121.1 hypothetical protein -
QE210_RS08210 (QE210_08180) 1688098..1688895 - 798 WP_280626122.1 hypothetical protein -
QE210_RS08215 (QE210_08185) 1689900..1690577 + 678 WP_280626123.1 ankyrin repeat domain-containing protein -
QE210_RS08220 (QE210_08190) 1690574..1690720 + 147 WP_280626124.1 hypothetical protein -
QE210_RS08225 (QE210_08195) 1690759..1690857 + 99 WP_280626126.1 hypothetical protein -
QE210_RS08230 (QE210_08200) 1691049..1692359 - 1311 WP_280626128.1 type II toxin-antitoxin system HipA family toxin Toxin
QE210_RS08235 (QE210_08205) 1692359..1692688 - 330 WP_026823614.1 helix-turn-helix transcriptional regulator Antitoxin
QE210_RS08240 (QE210_08210) 1692975..1693781 + 807 WP_280626130.1 2,5-didehydrogluconate reductase DkgB -
QE210_RS08245 (QE210_08215) 1693794..1694705 - 912 WP_280626131.1 DNA-binding transcriptional regulator YafC -
QE210_RS08250 (QE210_08220) 1694932..1695522 + 591 WP_026823615.1 NAD(P)H-dependent oxidoreductase -
QE210_RS08255 (QE210_08225) 1695721..1696290 - 570 WP_280626132.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(172-409)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-65)


Sequences

Toxin        


Download         Length: 437 a.a.        Molecular weight: 49288.37 Da        Isoelectric Point: 8.8242

>T279013 WP_280626128.1 NZ_CP123504:c1692359-1691049 [Arsenophonus nasoniae]
MEVINVNYKQHEVGAVSFDTSKGLGFFEYNSRFIKQGIELSPLKMPLATRIYSFPELDFNTFKGLPGLIADSLPDDFGNA
VLNAWVATMGKSPDTITPLQRLQYTGKRGMGALEYVPATRIKSLNASQQVEISSLVAITQEILDSRQKFTVELHKNGQED
REAMMALLSVGMSAGGARPKAVLAFNQDFTQVRSGQTNVPDGFTHYLIKFDGVSEHNKNQQTFGDPVGFGAMEYVYYLLA
TRCGIEMMPCRLLAEGNRRHFITQRFDRFGNKKRHVQTLNGLAHVDYKKPGSFSYAELFGVARQLKLSAKEAEQLLKRMT
FNIVAHNHDDHAKNFSFMLKGDKWMLAPAYDLAYSYKPGSKWVNSHWMSLNGKRDNFSRQDFYSLEKLSPLFTREMINGI
IDETIEKVSEWQKLAVEFAVPNLLAQEINANLCLNI

Download         Length: 1311 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12102.85 Da        Isoelectric Point: 6.4752

>AT279013 WP_026823614.1 NZ_CP123504:c1692688-1692359 [Arsenophonus nasoniae]
MSIFEESASAIAAELGERLKQARLNHDLTQAEVAELSGISRKTVLNAEKGNVQLENLIAIMAALNLLEQLDLFLPKQDIS
PIQLAKLQGKKRQRASGHRKNNTEDLAEW

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References