Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-MazE
Location 4967..5625 Replicon plasmid paPb4
Accession NZ_CP123503
Organism Arsenophonus sp. aPb

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QE177_RS15570 Protein ID WP_280552705.1
Coordinates 5233..5625 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QE177_RS15565 Protein ID WP_280552703.1
Coordinates 4967..5230 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QE177_RS15545 (QE177_15545) 828..2423 - 1596 WP_280552697.1 PD-(D/E)XK nuclease-like domain-containing protein -
QE177_RS15550 (QE177_15550) 2420..2731 - 312 WP_280552699.1 hypothetical protein -
QE177_RS15555 (QE177_15555) 2728..3351 - 624 WP_280552701.1 helix-turn-helix domain-containing protein -
QE177_RS15560 (QE177_15560) 3566..4264 - 699 WP_280552719.1 replication initiation protein -
QE177_RS15565 (QE177_15565) 4967..5230 + 264 WP_280552703.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
QE177_RS15570 (QE177_15570) 5233..5625 + 393 WP_280552705.1 type II toxin-antitoxin system VapC family toxin Toxin
QE177_RS15575 (QE177_15575) 5733..6095 - 363 WP_280552707.1 plasmid partitioning/stability family protein -
QE177_RS15580 (QE177_15580) 6098..7060 - 963 WP_280552709.1 plasmid segregation protein ParM -
QE177_RS15585 (QE177_15585) 7315..8457 - 1143 WP_280552712.1 cytosine permease -
QE177_RS15590 (QE177_15590) 8540..9223 - 684 WP_280548476.1 IS6 family transposase -
QE177_RS15595 (QE177_15595) 9354..9479 + 126 WP_280552714.1 hypothetical protein -
QE177_RS15600 (QE177_15600) 9543..10226 + 684 WP_280548476.1 IS6 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..27155 27155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-117)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14719.29 Da        Isoelectric Point: 10.1279

>T279012 WP_280552705.1 NZ_CP123503:5233-5625 [Arsenophonus sp. aPb]
MYMLDTNIVSHLFRKNQLVIKKLNNIPPSKVCISSITQAELLYGVAKRNNKALKKLVNIFLNSIEIIDWNEKDARVYGEL
RAKMESKGHVMGSLDMLIAAHALSRKKTIVTNDNAFSMATGLLVEDWTKE

Download         Length: 393 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10433.81 Da        Isoelectric Point: 9.9618

>AT279012 WP_280552703.1 NZ_CP123503:4967-5230 [Arsenophonus sp. aPb]
MEKMAKIFRNGSNQAVRLPVQFQFNTDRVYIRKNDKGDVILSKNKFYRNDWTEFLNILNQISLSDDFLDSKERKQDLTKR
DPFSEIN

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References