Detailed information of TA system TA027901

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 831028..831557
• Replicon: chromosome
• Accession: NC_018010
• Organism: Belliella baltica DSM 15883

Toxin (Protein)

• Gene name: parE
• Uniprot ID: I3Z2H1
• Locus tag: BELBA_RS03890
• Protein ID: WP_014771447.1
• Coordinates: 831028..831321 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: I3Z2H2
• Locus tag: BELBA_RS03895
• Protein ID: WP_014771448.1
• Coordinates: 831324..831557 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BELBA_RS19580	826445..826672	+	228	WP_014771441.1	hypothetical protein	-
BELBA_RS03865	826737..827807	+	1071	WP_157466052.1	6-bladed beta-propeller	-
BELBA_RS03870	828087..828416	+	330	WP_014771443.1	metalloregulator ArsR/SmtB family transcription factor	-
BELBA_RS03875	828498..829040	+	543	WP_014771444.1	hypothetical protein	-
BELBA_RS03880	829124..829735	+	612	WP_041779222.1	protein-tyrosine-phosphatase	-
BELBA_RS03885	829998..831026	+	1029	WP_014771446.1	ACR3 family arsenite efflux transporter	-
BELBA_RS03890	831028..831321	-	294	WP_014771447.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BELBA_RS03895	831324..831557	-	234	WP_014771448.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
BELBA_RS19950	831720..834176	+	2457	Protein_774	histidine kinase	-
BELBA_RS03905	834176..834928	+	753	WP_014771449.1	LytTR family DNA-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-91)

Antitoxin

• Antitoxin ParD (4-70)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11689.66 Da
• Isoelectric Point: 8.8513

>T27901 WP_014771447.1 NC_018010:c831321-831028 [Belliella baltica DSM 15883]
MAFFLTKKAKDDLKTIARYTHKEWGIRQRDNYLKQLDDVFFSLSIAPEKGLKCDYIRLNYRKFWVGRHIVFYLLIDNLDI
EIVRILHESMDIEVHLG

Nucleotide

• Length: 294 bp

>T27901 NC_018010:c831321-831028 [Belliella baltica DSM 15883]
TTGGCATTTTTTTTAACCAAAAAAGCAAAAGATGACTTAAAAACAATTGCCCGATACACCCATAAAGAATGGGGGATCAG
ACAAAGGGATAATTATTTAAAGCAGCTTGATGATGTGTTTTTTTCTTTGTCCATAGCTCCAGAAAAAGGTCTTAAATGTG
ACTATATCCGTTTAAACTACCGGAAGTTTTGGGTTGGTCGACATATAGTTTTTTATCTTCTAATTGATAATTTAGACATT
GAAATAGTTAGGATTTTGCATGAAAGTATGGACATTGAAGTTCATCTTGGTTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8490.41 Da
• Isoelectric Point: 4.4750

>AT27901 WP_014771448.1 NC_018010:c831557-831324 [Belliella baltica DSM 15883]
MSKNTSITLGSHFEDFISKQIENGRYGSASETVRAALRLLEEKETKLAAIRQALSEGEASGRADYSLDSLIEELNLE

Nucleotide

• Length: 234 bp

>AT27901 NC_018010:c831557-831324 [Belliella baltica DSM 15883]
ATGTCAAAAAATACAAGTATAACGCTGGGATCTCATTTTGAAGATTTTATAAGCAAGCAAATTGAGAATGGCAGATATGG
TTCAGCAAGTGAAACTGTACGGGCTGCTTTAAGACTTTTAGAGGAAAAGGAAACAAAATTGGCTGCTATAAGACAGGCTT
TATCTGAGGGAGAGGCAAGTGGAAGAGCCGATTATTCATTAGATTCATTAATTGAAGAACTTAACTTAGAATAA

Structures

Toxin

• AlphaFold DB: I3Z2H1

Antitoxin

• AlphaFold DB: I3Z2H2