Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1576971..1578610 Replicon chromosome
Accession NZ_CP123499
Organism Arsenophonus sp. aPb

Toxin (Protein)


Gene name HipA3 Uniprot ID -
Locus tag QE177_RS07015 Protein ID WP_280552152.1
Coordinates 1576971..1578287 (-) Length 439 a.a.

Antitoxin (Protein)


Gene name HipB3 Uniprot ID -
Locus tag QE177_RS07020 Protein ID WP_280552153.1
Coordinates 1578281..1578610 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QE177_RS06995 (QE177_06995) 1573982..1574428 - 447 WP_280552148.1 hypothetical protein -
QE177_RS07000 (QE177_07000) 1574513..1574779 - 267 WP_280552149.1 hypothetical protein -
QE177_RS07005 (QE177_07005) 1575758..1576435 + 678 WP_280552150.1 ankyrin repeat domain-containing protein -
QE177_RS07010 (QE177_07010) 1576432..1576899 + 468 WP_280552151.1 nucleoside deaminase -
QE177_RS07015 (QE177_07015) 1576971..1578287 - 1317 WP_280552152.1 type II toxin-antitoxin system HipA family toxin Toxin
QE177_RS07020 (QE177_07020) 1578281..1578610 - 330 WP_280552153.1 helix-turn-helix transcriptional regulator Antitoxin
QE177_RS07025 (QE177_07025) 1578897..1579703 + 807 WP_280552154.1 2,5-didehydrogluconate reductase DkgB -
QE177_RS07030 (QE177_07030) 1579716..1580627 - 912 WP_280552155.1 DNA-binding transcriptional regulator YafC -
QE177_RS07035 (QE177_07035) 1580857..1581447 + 591 WP_280552156.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(174-412)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-63)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 49528.73 Da        Isoelectric Point: 8.8253

>T279008 WP_280552152.1 NZ_CP123499:c1578287-1576971 [Arsenophonus sp. aPb]
MVMEVINVTYKQHEVGAVSFDTSKGLGFFEYNASFIKQGIELSPLKMPLATRIYSFPELDFNTFKGLPGLIADSLPDDFG
NAVLNAWVATMGKSPDTITPLQRLQYTGKRGMGALEYVPATRIKSLNASQHVEISSLVAITQEILDSRQKFTVELHKNGQ
EDREAMMALLSVGMSAGGARPKAVLAFNHDFTQVRSGQTNVPDGFTHYLIKFDGVSEHNKNQQTFGDPVGFGAMEYVYYL
LATRCGIEMMPCRLLAEGNRRHFITQRFDRFGNKKRHVQTLNGLAHVDYKKPGSFSYAELFAVARQLKLSAKEAEQLLKR
MTFNIVARNHDDHAKNFSFMLKGDKWMLAPAYDLAYSYKPGSKWVNSHWMSLNGKRDNFSRQDFYSLEKLSPLFTREMIN
GIIDETIEKVSQWQKLAVEFEVPNLLAQEINANLCLNI

Download         Length: 1317 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12076.91 Da        Isoelectric Point: 8.6807

>AT279008 WP_280552153.1 NZ_CP123499:c1578610-1578281 [Arsenophonus sp. aPb]
MSIFEKSASAIAAELGERLKQARLNHDLTQAEVAEMSGISRKTVLNAEKGNVQLENLIAIMAALNLLEQLDLLLPKQDIS
PIQLAKLQGKKRQRASGQRKNNTEDLAEW

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References