Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1800986..1802625 Replicon chromosome
Accession NZ_CP123498
Organism Arsenophonus nasoniae strain aIh

Toxin (Protein)


Gene name HipA3 Uniprot ID -
Locus tag QE207_RS10855 Protein ID WP_280628594.1
Coordinates 1800986..1802302 (-) Length 439 a.a.

Antitoxin (Protein)


Gene name HipB3 Uniprot ID -
Locus tag QE207_RS10860 Protein ID WP_026823614.1
Coordinates 1802296..1802625 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QE207_RS10835 (QE207_10825) 1797983..1798780 - 798 WP_280628591.1 hypothetical protein -
QE207_RS10840 (QE207_10830) 1799774..1800451 + 678 WP_280628592.1 ankyrin repeat domain-containing protein -
QE207_RS10845 (QE207_10835) 1800448..1800585 + 138 WP_280628593.1 hypothetical protein -
QE207_RS10850 (QE207_10840) 1800696..1800794 + 99 WP_280626126.1 hypothetical protein -
QE207_RS10855 (QE207_10845) 1800986..1802302 - 1317 WP_280628594.1 type II toxin-antitoxin system HipA family toxin Toxin
QE207_RS10860 (QE207_10850) 1802296..1802625 - 330 WP_026823614.1 helix-turn-helix transcriptional regulator Antitoxin
QE207_RS10865 (QE207_10855) 1802912..1803718 + 807 WP_280628595.1 2,5-didehydrogluconate reductase DkgB -
QE207_RS10870 (QE207_10860) 1803731..1804642 - 912 WP_280628596.1 DNA-binding transcriptional regulator YafC -
QE207_RS10875 (QE207_10865) 1804870..1805460 + 591 WP_026823615.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(174-411)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-65)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 49537.74 Da        Isoelectric Point: 9.0448

>T279004 WP_280628594.1 NZ_CP123498:c1802302-1800986 [Arsenophonus nasoniae]
MVMEVINVNYKQHEVGAVSFDTSKGLGFFEYNSRFIKQGIELSPLKMPLATRIYSFPELDFNTFKGLPGLIADSLPDDFG
NAVLNAWVATMGKSPDTITPLQRLQYTGKRGMGALEYVPATRIKSLNASQQVEISSLVAITQEILDSRQKFTVELHKNGQ
EDREAMMALLSVGMSAGGARPKAVLAFNQDFTQVRSGQTNVPDGFTHYLIKFDGVSEHNKNQQTFGDPVGFGAMEYVYYL
LATRCGIEMMPCRLLAEGNRRHFITQRFDRFGNKKRHVQTLNGLAHVDYKKPGSFSYAELFGVARQLKLSAKEAEQLLKR
MTFNIVARNHDDHAKNFSFMLKGDKWMLAPAYDLAYSYKPGSKWVNSHWMSLNGKRDNFSRQDFYSLEKLSPLFTREMIN
GIIDETIEKVSEWQKLAVEFAVPNLLAQEINANLCLNI

Download         Length: 1317 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12102.85 Da        Isoelectric Point: 6.4752

>AT279004 WP_026823614.1 NZ_CP123498:c1802625-1802296 [Arsenophonus nasoniae]
MSIFEESASAIAAELGERLKQARLNHDLTQAEVAELSGISRKTVLNAEKGNVQLENLIAIMAALNLLEQLDLFLPKQDIS
PIQLAKLQGKKRQRASGHRKNNTEDLAEW

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References