Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 51510..52146 Replicon plasmid paIh2
Accession NZ_CP123492
Organism Arsenophonus nasoniae strain aIh

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag QE207_RS00915 Protein ID WP_280628348.1
Coordinates 51510..51686 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QE207_RS00920 Protein ID WP_280628349.1
Coordinates 51736..52146 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QE207_RS00885 (QE207_00885) 46606..47805 + 1200 WP_280624651.1 IS91 family transposase -
QE207_RS00890 (QE207_00890) 48119..49395 + 1277 Protein_52 cytosine permease -
QE207_RS00895 (QE207_00895) 49647..49865 - 219 WP_280628306.1 type II toxin-antitoxin system MqsA family antitoxin -
QE207_RS00900 (QE207_00900) 49858..50112 - 255 WP_280628307.1 hypothetical protein -
QE207_RS00905 (QE207_00905) 50109..50651 - 543 WP_280628308.1 hypothetical protein -
QE207_RS00910 (QE207_00910) 50783..51295 - 513 WP_280628309.1 J domain-containing protein -
QE207_RS00915 (QE207_00915) 51510..51686 + 177 WP_280628348.1 type II toxin-antitoxin system HicA family toxin Toxin
QE207_RS00920 (QE207_00920) 51736..52146 + 411 WP_280628349.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QE207_RS00925 (QE207_00925) 52532..53293 - 762 WP_280628310.1 IS21-like element helper ATPase IstB -
QE207_RS00930 (QE207_00930) 53280..54056 - 777 Protein_60 IS21 family transposase -
QE207_RS00935 (QE207_00935) 54088..57117 - 3030 WP_280628311.1 Tn3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..64846 64846


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6709.83 Da        Isoelectric Point: 11.6882

>T278997 WP_280628348.1 NZ_CP123492:51510-51686 [Arsenophonus nasoniae]
VKQSEFRRWLEAQGVEISNGTNHLKLRFNGKRSVMPRHPSAEIKEPTRKAILKQLGLK

Download         Length: 177 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15150.46 Da        Isoelectric Point: 5.2431

>AT278997 WP_280628349.1 NZ_CP123492:51736-52146 [Arsenophonus nasoniae]
MRYPVNLTACKEGGFSVTFPDIPEAITQGENREEALKMALDALVTAFEFYFEDNEAIPAPSPVRADFVEVPAAVVAKVLL
LNQFAKSEMSQSELARRMHCPRQEVTRLFDLKHNTKINTVQKALAVLGQRLELSVA

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References