Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4017653..4018356 Replicon chromosome
Accession NZ_CP123488
Organism Kluyvera intermedia strain DW18

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag QBD33_RS19325 Protein ID WP_275388215.1
Coordinates 4017653..4017994 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag QBD33_RS19330 Protein ID WP_275388216.1
Coordinates 4018015..4018356 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBD33_RS19315 (4015392) 4015392..4016036 - 645 Protein_3777 integrase arm-type DNA-binding domain-containing protein -
QBD33_RS19320 (4016382) 4016382..4017389 - 1008 WP_275388214.1 restriction endonuclease -
QBD33_RS19325 (4017653) 4017653..4017994 - 342 WP_275388215.1 TA system toxin CbtA family protein Toxin
QBD33_RS19330 (4018015) 4018015..4018356 - 342 WP_275388216.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QBD33_RS19335 (4018367) 4018367..4018909 - 543 WP_275388217.1 DNA repair protein RadC -
QBD33_RS19340 (4018922) 4018922..4019398 - 477 WP_275388218.1 antirestriction protein -
QBD33_RS19345 (4019642) 4019642..4020460 - 819 WP_275388219.1 DUF932 domain-containing protein -
QBD33_RS19350 (4020670) 4020670..4021296 - 627 WP_275388220.1 hypothetical protein -
QBD33_RS19355 (4021301) 4021301..4021852 - 552 WP_275388221.1 hypothetical protein -
QBD33_RS19360 (4022158) 4022158..4023039 - 882 WP_275388222.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4014180..4021852 7672
- inside Prophage - - 4004487..4039807 35320


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(13-111)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12827.80 Da        Isoelectric Point: 9.8952

>T278995 WP_275388215.1 NZ_CP123488:c4017994-4017653 [Kluyvera intermedia]
MKTLSATTPQAATLYLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQKHIDTGISLADAVNFLVEKYGLVRIDRRGF
DWQEQSPYLRAVDILRARQATGLLKRNRISAVR

Download         Length: 342 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12826.36 Da        Isoelectric Point: 5.4855

>AT278995 WP_275388216.1 NZ_CP123488:c4018356-4018015 [Kluyvera intermedia]
MKSTDSENDSFLQWGLNCNVTPCFGARLVQEGNRLHYLADRACITGEFSNAESLKLDEVFTRFISQMESMLTTGEMNPRH
AHCVTLYHNGFTCEADTLGSYGYVYITVYPTHR

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References