Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3470348..3470966 Replicon chromosome
Accession NZ_CP123488
Organism Kluyvera intermedia strain DW18

Toxin (Protein)


Gene name Hha Uniprot ID A0A447MKF0
Locus tag QBD33_RS16835 Protein ID WP_062773821.1
Coordinates 3470748..3470966 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag QBD33_RS16830 Protein ID WP_280556207.1
Coordinates 3470348..3470722 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBD33_RS16820 (3465427) 3465427..3468573 + 3147 WP_280556206.1 multidrug efflux RND transporter permease subunit AcrB -
QBD33_RS16830 (3470348) 3470348..3470722 + 375 WP_280556207.1 Hha toxicity modulator TomB Antitoxin
QBD33_RS16835 (3470748) 3470748..3470966 + 219 WP_062773821.1 HHA domain-containing protein Toxin
QBD33_RS16840 (3471107) 3471107..3471661 + 555 WP_062773823.1 maltose O-acetyltransferase -
QBD33_RS16845 (3471765) 3471765..3472235 + 471 WP_280556208.1 YlaC family protein -
QBD33_RS16850 (3472210) 3472210..3473655 - 1446 WP_280556209.1 PLP-dependent aminotransferase family protein -
QBD33_RS16855 (3473758) 3473758..3474468 + 711 WP_280556211.1 GNAT family protein -
QBD33_RS16860 (3474465) 3474465..3474605 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
QBD33_RS16865 (3474605) 3474605..3474868 - 264 WP_052283831.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8624.01 Da        Isoelectric Point: 8.9008

>T278994 WP_062773821.1 NZ_CP123488:3470748-3470966 [Kluyvera intermedia]
MSDKPLTKTDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPTVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14310.11 Da        Isoelectric Point: 5.5770

>AT278994 WP_280556207.1 NZ_CP123488:3470348-3470722 [Kluyvera intermedia]
MDEYSPKRHDIAQLKFLCETLYHDSLATLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYSKDNKLIAQIDEYL
DDTFMLFGNYGVNSDDLQKWRKSGNKLFRCFVNASRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A447MKF0

Antitoxin

Source ID Structure

References