Detailed information of TA system TA027899

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/YoeB-DinJ
• Location: 1542238..1542767
• Replicon: chromosome
• Accession: NC_018002
• Organism: Sulfurospirillum barnesii SES-3

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: I3XY30
• Locus tag: SULBA_RS07750
• Protein ID: WP_014769732.1
• Coordinates: 1542238..1542507 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: I3XY31
• Locus tag: SULBA_RS07755
• Protein ID: WP_014769733.1
• Coordinates: 1542504..1542767 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SULBA_RS07720	1537912..1539039	-	1128	WP_014769726.1	CCA tRNA nucleotidyltransferase	-
SULBA_RS07725	1539036..1539419	-	384	WP_041671830.1	hypothetical protein	-
SULBA_RS07730	1539410..1539658	-	249	WP_014769728.1	hypothetical protein	-
SULBA_RS07735	1539655..1540728	-	1074	WP_014769729.1	3-isopropylmalate dehydrogenase	-
SULBA_RS07740	1540725..1541213	-	489	WP_014769730.1	3-isopropylmalate dehydratase small subunit	-
SULBA_RS07745	1541442..1542200	+	759	WP_014769731.1	hypothetical protein	-
SULBA_RS07750	1542238..1542507	-	270	WP_014769732.1	Txe/YoeB family addiction module toxin	Toxin
SULBA_RS07755	1542504..1542767	-	264	WP_014769733.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
SULBA_RS07760	1542823..1543620	-	798	WP_014769734.1	ATP-binding cassette domain-containing protein	-
SULBA_RS07765	1543746..1544060	+	315	WP_014769735.1	metalloregulator ArsR/SmtB family transcription factor	-
SULBA_RS07770	1544057..1545310	+	1254	WP_014769736.1	arsenic transporter	-
SULBA_RS07775	1545429..1547042	+	1614	WP_014769737.1	methyl-accepting chemotaxis protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-86)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-50)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10629.04 Da
• Isoelectric Point: 7.9819

>T27899 WP_014769732.1 NC_018002:c1542507-1542238 [Sulfurospirillum barnesii SES-3]
MSYSIVFTQIAWDEYLSWQSEDKKTLKRINQLLSDIMRNGNSGIGKPERLRGDLSEYWSRRIDEKNRIVYRIVEESIEVV
QCKTHYADK

Nucleotide

• Length: 270 bp

>T27899 NC_018002:c1542507-1542238 [Sulfurospirillum barnesii SES-3]
ATGAGCTACTCAATCGTTTTTACGCAGATAGCGTGGGACGAATATTTATCGTGGCAGAGTGAGGATAAAAAGACGCTAAA
ACGCATCAATCAACTCTTATCAGACATCATGCGAAATGGTAACTCAGGCATCGGTAAACCTGAACGGCTAAGAGGCGATT
TGTCGGAGTATTGGAGTCGTAGGATTGATGAGAAAAACCGCATCGTTTACCGCATTGTAGAAGAGTCCATCGAAGTGGTA
CAATGCAAAACGCATTATGCGGATAAGTAG

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9956.40 Da
• Isoelectric Point: 6.3285

>AT27899 WP_014769733.1 NC_018002:c1542767-1542504 [Sulfurospirillum barnesii SES-3]
MAQVNINIRMDETVKKQAEELFNELGLNMTTAFNMFVRQALNRGGIPFEVVRKDAFYSPYNQEKLRESIASTDKTVKSLD
ALEKLAQ

Nucleotide

• Length: 264 bp

>AT27899 NC_018002:c1542767-1542504 [Sulfurospirillum barnesii SES-3]
ATGGCGCAAGTAAACATCAATATCCGCATGGATGAAACAGTCAAAAAACAAGCCGAAGAGCTTTTTAATGAGTTAGGGCT
TAACATGACCACAGCGTTTAACATGTTTGTTCGTCAAGCGCTCAACCGTGGTGGCATCCCTTTTGAAGTGGTGCGTAAAG
ATGCGTTTTATAGCCCGTACAATCAAGAAAAATTACGAGAATCCATCGCCAGTACCGACAAAACAGTAAAAAGCCTTGAT
GCGTTAGAAAAGCTAGCGCAATGA

Structures

Toxin

• AlphaFold DB: I3XY30

Antitoxin

• AlphaFold DB: I3XY31