Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 858935..859598 Replicon chromosome
Accession NZ_CP123488
Organism Kluyvera intermedia strain DW18

Toxin (Protein)


Gene name cptA Uniprot ID A0A3S4EYA3
Locus tag QBD33_RS04145 Protein ID WP_062773047.1
Coordinates 859182..859598 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A3S4FV25
Locus tag QBD33_RS04140 Protein ID WP_062773044.1
Coordinates 858935..859201 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QBD33_RS04115 (854090) 854090..855523 - 1434 WP_280557625.1 6-phospho-beta-glucosidase BglA -
QBD33_RS04120 (855644) 855644..856330 - 687 WP_062773031.1 MurR/RpiR family transcriptional regulator -
QBD33_RS04125 (856424) 856424..856738 + 315 WP_280557626.1 N(4)-acetylcytidine aminohydrolase -
QBD33_RS04130 (856897) 856897..857559 + 663 WP_280557628.1 hemolysin III family protein -
QBD33_RS04135 (857704) 857704..858687 - 984 WP_153742213.1 tRNA-modifying protein YgfZ -
QBD33_RS04140 (858935) 858935..859201 + 267 WP_062773044.1 FAD assembly factor SdhE Antitoxin
QBD33_RS04145 (859182) 859182..859598 + 417 WP_062773047.1 protein YgfX Toxin
QBD33_RS04150 (859595) 859595..860116 - 522 WP_280558770.1 flavodoxin FldB -
QBD33_RS04155 (860219) 860219..861115 + 897 WP_062773053.1 site-specific tyrosine recombinase XerD -
QBD33_RS04160 (861137) 861137..861850 + 714 WP_280557636.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QBD33_RS04165 (861856) 861856..863589 + 1734 WP_062773059.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 16416.32 Da        Isoelectric Point: 11.6889

>T278989 WP_062773047.1 NZ_CP123488:859182-859598 [Kluyvera intermedia]
VVLWQSDLRVSWRSQWLSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSLVVFDCVRSQRRIHSHQGEIKLLMDSRLRWRNQ
EWDILGTPWMLSSGMMLRIRRCDGGRRQHLWLAADSMNAQEWRDLRRILLQQPAPGQH

Download         Length: 417 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10507.00 Da        Isoelectric Point: 5.6125

>AT278989 WP_062773044.1 NZ_CP123488:858935-859201 [Kluyvera intermedia]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDEDKTVFIRLLECDDPDLFNWLMNHGKPANADFQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S4EYA3

Antitoxin

Source ID Structure
AlphaFold DB A0A3S4FV25

References