Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 56536..57446 Replicon plasmid pYUSHP16-1
Accession NZ_CP123431
Organism Klebsiella pneumoniae strain SH22PE16

Toxin (Protein)


Gene name - Uniprot ID R4YBC5
Locus tag QEZ34_RS25075 Protein ID WP_004144067.1
Coordinates 56976..57446 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6A8PHD0
Locus tag QEZ34_RS25070 Protein ID WP_023287184.1
Coordinates 56536..56979 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEZ34_RS25055 51835..53016 + 1182 WP_023287181.1 hypothetical protein -
QEZ34_RS25060 53013..55241 + 2229 WP_032430744.1 ThiF family adenylyltransferase -
QEZ34_RS25065 55294..56435 + 1142 Protein_52 translesion error-prone DNA polymerase V subunit UmuC -
QEZ34_RS25070 56536..56979 + 444 WP_023287184.1 DUF2384 domain-containing protein Antitoxin
QEZ34_RS25075 56976..57446 + 471 WP_004144067.1 RES family NAD+ phosphorylase Toxin
QEZ34_RS25080 57533..57853 + 321 Protein_55 IS5/IS1182 family transposase -
QEZ34_RS25085 57886..58854 + 969 WP_074423483.1 IS5 family transposase -
QEZ34_RS25090 59193..60404 - 1212 WP_017901247.1 M24 family metallopeptidase -
QEZ34_RS25095 60491..61444 - 954 WP_020481021.1 LysR substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mph(A) / sul2 pla 1..218903 218903


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17573.83 Da        Isoelectric Point: 4.5152

>T278985 WP_004144067.1 NZ_CP123431:56976-57446 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16522.84 Da        Isoelectric Point: 10.3013

>AT278985 WP_023287184.1 NZ_CP123431:56536-56979 [Klebsiella pneumoniae]
MKTFSLSSSPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A384IED8

Antitoxin

Source ID Structure
AlphaFold DB A0A6A8PHD0

References