Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4543723..4544239 Replicon chromosome
Accession NZ_CP123430
Organism Klebsiella pneumoniae strain SH22PE16

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag QEZ34_RS22110 Protein ID WP_002886902.1
Coordinates 4543723..4544007 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag QEZ34_RS22115 Protein ID WP_002886901.1
Coordinates 4543997..4544239 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEZ34_RS22085 (4539118) 4539118..4539381 - 264 WP_228985702.1 PTS sugar transporter subunit IIB -
QEZ34_RS22090 (4539511) 4539511..4539684 + 174 WP_002886906.1 hypothetical protein -
QEZ34_RS22095 (4539687) 4539687..4540430 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
QEZ34_RS22100 (4540787) 4540787..4542925 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
QEZ34_RS22105 (4543255) 4543255..4543719 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QEZ34_RS22110 (4543723) 4543723..4544007 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QEZ34_RS22115 (4543997) 4543997..4544239 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QEZ34_RS22120 (4544317) 4544317..4546227 - 1911 WP_009486549.1 PRD domain-containing protein -
QEZ34_RS22125 (4546250) 4546250..4547404 - 1155 WP_002886900.1 lactonase family protein -
QEZ34_RS22130 (4547471) 4547471..4548211 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T278982 WP_002886902.1 NZ_CP123430:c4544007-4543723 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT278982 WP_002886901.1 NZ_CP123430:c4544239-4543997 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References