Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3828921..3829540 Replicon chromosome
Accession NZ_CP123430
Organism Klebsiella pneumoniae strain SH22PE16

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag QEZ34_RS18710 Protein ID WP_002892050.1
Coordinates 3829322..3829540 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag QEZ34_RS18705 Protein ID WP_002892066.1
Coordinates 3828921..3829295 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEZ34_RS18695 (3824073) 3824073..3825266 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QEZ34_RS18700 (3825289) 3825289..3828435 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
QEZ34_RS18705 (3828921) 3828921..3829295 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
QEZ34_RS18710 (3829322) 3829322..3829540 + 219 WP_002892050.1 HHA domain-containing protein Toxin
QEZ34_RS18715 (3829699) 3829699..3830265 + 567 WP_002892030.1 maltose O-acetyltransferase -
QEZ34_RS18720 (3830237) 3830237..3830377 - 141 WP_004147370.1 hypothetical protein -
QEZ34_RS18725 (3830398) 3830398..3830868 + 471 WP_002892026.1 YlaC family protein -
QEZ34_RS18730 (3830843) 3830843..3832294 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
QEZ34_RS18735 (3832395) 3832395..3833093 + 699 WP_004177238.1 GNAT family protein -
QEZ34_RS18740 (3833090) 3833090..3833230 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
QEZ34_RS18745 (3833230) 3833230..3833493 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T278980 WP_002892050.1 NZ_CP123430:3829322-3829540 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T278980 NZ_CP123430:3829322-3829540 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT278980 WP_002892066.1 NZ_CP123430:3828921-3829295 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT278980 NZ_CP123430:3828921-3829295 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References