Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2570583..2572171 Replicon chromosome
Accession NZ_CP123430
Organism Klebsiella pneumoniae strain SH22PE16

Toxin (Protein)


Gene name hipA Uniprot ID A0A486RAG1
Locus tag QEZ34_RS12655 Protein ID WP_016946382.1
Coordinates 2570583..2571905 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag QEZ34_RS12660 Protein ID WP_002904790.1
Coordinates 2571905..2572171 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEZ34_RS12640 (2565639) 2565639..2568140 + 2502 WP_023282574.1 fimbria/pilus outer membrane usher protein -
QEZ34_RS12645 (2568128) 2568128..2569132 + 1005 WP_016946380.1 fimbrial protein -
QEZ34_RS12650 (2569274) 2569274..2570566 + 1293 WP_016946381.1 glycoside hydrolase family 10 protein -
QEZ34_RS12655 (2570583) 2570583..2571905 - 1323 WP_016946382.1 type II toxin-antitoxin system HipA family toxin Toxin
QEZ34_RS12660 (2571905) 2571905..2572171 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QEZ34_RS12665 (2572558) 2572558..2572884 - 327 WP_004215084.1 hydroxyisourate hydrolase -
QEZ34_RS12670 (2572881) 2572881..2573381 - 501 WP_023282573.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
QEZ34_RS12675 (2573359) 2573359..2574738 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
QEZ34_RS12680 (2575084) 2575084..2576238 + 1155 WP_023282572.1 FAD-dependent urate hydroxylase HpxO -
QEZ34_RS12685 (2576219) 2576219..2577142 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49125.44 Da        Isoelectric Point: 7.5358

>T278979 WP_016946382.1 NZ_CP123430:c2571905-2570583 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT278979 WP_002904790.1 NZ_CP123430:c2572171-2571905 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486RAG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References