Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 1010139..1010737 Replicon chromosome
Accession NZ_CP123403
Organism Trueperella pyogenes strain 13OD0707

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag QEV10_RS04370 Protein ID WP_108726552.1
Coordinates 1010423..1010737 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag QEV10_RS04365 Protein ID WP_108726551.1
Coordinates 1010139..1010432 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEV10_RS04335 (QEV10_04335) 1005569..1006216 - 648 WP_039661760.1 5-formyltetrahydrofolate cyclo-ligase -
QEV10_RS04340 (QEV10_04340) 1006300..1007514 + 1215 WP_039661762.1 molybdopterin molybdotransferase MoeA -
QEV10_RS04345 (QEV10_04345) 1007574..1008593 + 1020 WP_283839989.1 hypothetical protein -
QEV10_RS04350 (QEV10_04350) 1008590..1009216 + 627 WP_108726549.1 alpha/beta fold hydrolase -
QEV10_RS04360 (QEV10_04360) 1009616..1010032 - 417 WP_108726550.1 SRPBCC family protein -
QEV10_RS04365 (QEV10_04365) 1010139..1010432 - 294 WP_108726551.1 putative addiction module antidote protein Antitoxin
QEV10_RS04370 (QEV10_04370) 1010423..1010737 - 315 WP_108726552.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QEV10_RS04375 (QEV10_04375) 1011130..1011915 + 786 WP_260145384.1 siderophore-interacting protein -
QEV10_RS04380 (QEV10_04380) 1012243..1012599 + 357 WP_039661774.1 hypothetical protein -
QEV10_RS04385 (QEV10_04385) 1012731..1013354 - 624 WP_230589887.1 alpha/beta hydrolase -
QEV10_RS04390 (QEV10_04390) 1013486..1014439 - 954 WP_108726554.1 SRPBCC family protein -
QEV10_RS04395 (QEV10_04395) 1014436..1014678 - 243 WP_024963636.1 hypothetical protein -
QEV10_RS04400 (QEV10_04400) 1014787..1015704 + 918 WP_283839991.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 998989..1013354 14365


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-96)

Antitoxin

Uncharacterized protein HI1420

(4-93)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11875.76 Da        Isoelectric Point: 10.0302

>T278972 WP_108726552.1 NZ_CP123403:c1010737-1010423 [Trueperella pyogenes]
VKIRQTDVYAHWFRELKDVQSKARINIALQRCKIAGEVVGDVKPVGDGVFEMRIHVGPGYRIYYMSRGNQLMLLVIGGDK
STQQRDITKAKQLATEIIREGSWE

Download         Length: 315 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10273.77 Da        Isoelectric Point: 4.8004

>AT278972 WP_108726551.1 NZ_CP123403:c1010432-1010139 [Trueperella pyogenes]
MGVKISTWDASEYLETKEDIAAYLNAALEEGDPALLQVALGDVAKARGVTAIAREAGVGRESLYKSLSENGNPSWRTITK
VLTALGLKIEVKAIALA

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References