Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pezAT/zeta-ParD |
| Location | 4608763..4609718 | Replicon | chromosome |
| Accession | NZ_CP123381 | ||
| Organism | Gordonia sp. SMJS1 | ||
Toxin (Protein)
| Gene name | pezT | Uniprot ID | - |
| Locus tag | QAD21_RS20885 | Protein ID | WP_247450284.1 |
| Coordinates | 4608763..4609338 (-) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | pezA | Uniprot ID | - |
| Locus tag | QAD21_RS20890 | Protein ID | WP_280360210.1 |
| Coordinates | 4609335..4609718 (-) | Length | 128 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QAD21_RS20860 (QAD21_20860) | 4605015..4606022 | + | 1008 | WP_280360206.1 | LacI family DNA-binding transcriptional regulator | - |
| QAD21_RS20865 (QAD21_20865) | 4606026..4606343 | - | 318 | WP_280360207.1 | DUF2470 domain-containing protein | - |
| QAD21_RS20870 (QAD21_20870) | 4606336..4607067 | - | 732 | WP_280360208.1 | tyrosine-protein phosphatase | - |
| QAD21_RS20875 (QAD21_20875) | 4607160..4607792 | + | 633 | WP_280361819.1 | flavin reductase family protein | - |
| QAD21_RS20880 (QAD21_20880) | 4607819..4608766 | - | 948 | WP_280360209.1 | PfkB family carbohydrate kinase | - |
| QAD21_RS20885 (QAD21_20885) | 4608763..4609338 | - | 576 | WP_247450284.1 | zeta toxin family protein | Toxin |
| QAD21_RS20890 (QAD21_20890) | 4609335..4609718 | - | 384 | WP_280360210.1 | hypothetical protein | Antitoxin |
| QAD21_RS20895 (QAD21_20895) | 4609842..4610390 | - | 549 | WP_280360211.1 | peptide-methionine (S)-S-oxide reductase MsrA | - |
| QAD21_RS20900 (QAD21_20900) | 4610387..4610881 | - | 495 | WP_280360212.1 | peptide-methionine (R)-S-oxide reductase MsrB | - |
| QAD21_RS20905 (QAD21_20905) | 4611038..4612261 | - | 1224 | WP_277244056.1 | acyl-CoA dehydrogenase family protein | - |
| QAD21_RS20910 (QAD21_20910) | 4612317..4613405 | - | 1089 | WP_205333371.1 | VOC family protein | - |
| QAD21_RS20915 (QAD21_20915) | 4613652..4614545 | + | 894 | WP_078113761.1 | acetaldehyde dehydrogenase (acetylating) | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21202.34 Da Isoelectric Point: 10.1705
>T278971 WP_247450284.1 NZ_CP123381:c4609338-4608763 [Gordonia sp. SMJS1]
VTPRLDLVVGCNGAGKSTLVERHLQPLLHVPFVNADLIARQRWPDSAEAHSYDAARLAAATRDTLIERGTSFIAETVFSH
PSKLELIERAHTAGYRVALHVVMIPEALAVHRVRLRVDSGGHAVPEVKIRERFRRLWPLVRTAIARSDLATVYANERPTT
RIVARYVDGLVAGVPDWPDWTPGALTDTKAR
VTPRLDLVVGCNGAGKSTLVERHLQPLLHVPFVNADLIARQRWPDSAEAHSYDAARLAAATRDTLIERGTSFIAETVFSH
PSKLELIERAHTAGYRVALHVVMIPEALAVHRVRLRVDSGGHAVPEVKIRERFRRLWPLVRTAIARSDLATVYANERPTT
RIVARYVDGLVAGVPDWPDWTPGALTDTKAR
Download Length: 576 bp
Antitoxin
Download Length: 128 a.a. Molecular weight: 13655.07 Da Isoelectric Point: 4.9732
>AT278971 WP_280360210.1 NZ_CP123381:c4609718-4609335 [Gordonia sp. SMJS1]
MSTGTDKVTRLSAALVTDAAREGAREQRSARQQLEHWARLGRSVSQRTTASRQRVEAALAGDLPGEVLTAEEAVVYDAEI
DAHLEARLATDDHVVRRASAGLSSVVVDDAGQLVEHRPDGTSVILEQ
MSTGTDKVTRLSAALVTDAAREGAREQRSARQQLEHWARLGRSVSQRTTASRQRVEAALAGDLPGEVLTAEEAVVYDAEI
DAHLEARLATDDHVVRRASAGLSSVVVDDAGQLVEHRPDGTSVILEQ
Download Length: 384 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|