Detailed information of TA system TA027897

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): virT-relB/YafQ-RelB
• Location: 821856..822376
• Replicon: chromosome
• Accession: NC_018002
• Organism: Sulfurospirillum barnesii SES-3

Toxin (Protein)

• Gene name: virT
• Uniprot ID: I3XW20
• Locus tag: SULBA_RS04190
• Protein ID: WP_014769024.1
• Coordinates: 821856..822128 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: I3XW21
• Locus tag: SULBA_RS04195
• Protein ID: WP_014769025.1
• Coordinates: 822125..822376 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SULBA_RS04165	817549..817914	-	366	WP_014769019.1	DUF86 domain-containing protein	-
SULBA_RS04170	817907..818197	-	291	WP_014769020.1	nucleotidyltransferase domain-containing protein	-
SULBA_RS04175	818247..818630	-	384	WP_014769021.1	DndE family protein	-
SULBA_RS04180	818627..820375	-	1749	WP_014769022.1	AAA family ATPase	-
SULBA_RS04185	820362..821699	-	1338	WP_014769023.1	DNA phosphorothioation system sulfurtransferase DndC	-
SULBA_RS04190	821856..822128	-	273	WP_014769024.1	type II toxin-antitoxin system YafQ family toxin	Toxin
SULBA_RS04195	822125..822376	-	252	WP_014769025.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
SULBA_RS04200	822661..823212	-	552	WP_014769026.1	DNA-3-methyladenine glycosylase I	-
SULBA_RS04205	823382..823867	+	486	WP_014769027.1	CreA family protein	-
SULBA_RS04210	823991..824557	+	567	WP_014769028.1	YceI family protein	-
SULBA_RS04215	824756..825358	+	603	WP_014769029.1	TetR/AcrR family transcriptional regulator	-
SULBA_RS04220	825383..826321	-	939	WP_014769030.1	succinylglutamate desuccinylase/aspartoacylase family protein	-
SULBA_RS04225	826318..827265	-	948	WP_014769031.1	succinylglutamate desuccinylase/aspartoacylase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-82)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10475.36 Da
• Isoelectric Point: 8.9765

>T27897 WP_014769024.1 NC_018002:c822128-821856 [Sulfurospirillum barnesii SES-3]
MTYAIFRTSSFKKAYKKLASPEQELVLMIVLKLANGENLDEKYKDHFLIGNYKGCRECHIKPDLLLIYKINNDEVELVLV
EVGKHSKLFK

Nucleotide

• Length: 273 bp

>T27897 NC_018002:c822128-821856 [Sulfurospirillum barnesii SES-3]
ATGACATACGCTATCTTTCGTACCTCTTCTTTCAAAAAAGCCTACAAAAAGCTCGCTTCGCCTGAGCAAGAACTTGTTTT
AATGATTGTTTTAAAACTTGCTAACGGTGAAAATTTGGATGAAAAATACAAAGATCATTTTCTAATAGGCAATTACAAAG
GATGCAGGGAGTGTCACATTAAACCCGACTTACTGCTCATCTACAAAATCAATAACGATGAAGTGGAATTGGTTTTGGTA
GAGGTTGGTAAGCATTCTAAATTGTTTAAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9426.93 Da
• Isoelectric Point: 6.3502

>AT27897 WP_014769025.1 NC_018002:c822376-822125 [Sulfurospirillum barnesii SES-3]
MRTGTSVRIDEETKIIASEVLKQYGLSLSEGINLFCRQVAMTYSIPFELKVPTERMKKALKELEKREGKSFDSIEALKAD
LES

Nucleotide

• Length: 252 bp

>AT27897 NC_018002:c822376-822125 [Sulfurospirillum barnesii SES-3]
ATGAGAACAGGAACCAGTGTTCGTATTGATGAAGAGACAAAGATTATTGCTTCAGAAGTGTTAAAACAGTATGGTCTGAG
CCTGAGTGAAGGCATCAACCTTTTTTGTAGGCAAGTTGCGATGACGTATTCGATTCCCTTTGAATTAAAAGTACCAACAG
AACGCATGAAAAAAGCACTCAAAGAGCTAGAAAAAAGGGAAGGAAAATCCTTTGATTCCATCGAAGCACTCAAAGCTGAT
CTTGAGTCATGA

Structures

Toxin

• AlphaFold DB: I3XW20

Antitoxin

• AlphaFold DB: I3XW21