Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 8731..9311 Replicon plasmid p15793C_57
Accession NZ_CP123368
Organism Providencia rettgeri strain PreM15793

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag KOL65_RS21490 Protein ID WP_283656987.1
Coordinates 8731..9066 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag KOL65_RS21495 Protein ID WP_283656988.1
Coordinates 9066..9311 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KOL65_RS21455 (KOL65_21740) 4085..4267 - 183 WP_283656980.1 hypothetical protein -
KOL65_RS21460 (KOL65_21745) 4626..5846 - 1221 WP_283656981.1 DUF3560 domain-containing protein -
KOL65_RS21465 (KOL65_21750) 6045..6341 + 297 WP_283656982.1 type II toxin-antitoxin system RelE/ParE family toxin -
KOL65_RS21470 (KOL65_21755) 6343..6627 + 285 WP_283656983.1 putative addiction module antidote protein -
KOL65_RS21475 (KOL65_21760) 7073..7219 + 147 WP_283656984.1 Hok/Gef family protein -
KOL65_RS21480 (KOL65_21765) 7287..7622 - 336 WP_283656985.1 hypothetical protein -
KOL65_RS21485 (KOL65_21770) 7669..8706 - 1038 WP_283656986.1 hypothetical protein -
KOL65_RS21490 (KOL65_21775) 8731..9066 - 336 WP_283656987.1 endoribonuclease MazF Toxin
KOL65_RS21495 (KOL65_21780) 9066..9311 - 246 WP_283656988.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
KOL65_RS21500 (KOL65_21785) 10433..11407 + 975 WP_283656989.1 replication initiation protein -
KOL65_RS21505 (KOL65_21790) 11394..12221 + 828 WP_283656990.1 GIY-YIG nuclease family protein -
KOL65_RS21510 (KOL65_21795) 12356..12691 + 336 WP_283656991.1 hypothetical protein -
KOL65_RS21515 (KOL65_21800) 12786..13082 + 297 WP_283656992.1 LuxR C-terminal-related transcriptional regulator -
KOL65_RS21520 (KOL65_21805) 13248..13571 + 324 WP_283656993.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..57581 57581


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin

Antitoxin PemI-like

(3-80)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12078.91 Da        Isoelectric Point: 7.6697

>T278964 WP_283656987.1 NZ_CP123368:c9066-8731 [Providencia rettgeri]
MVSRYVPDSGDLIWINLDPVEGHEQGGHRPAVVLSPFAYNNKVGLLLCVPCTTKGKNYPFEVELSCSGNESFALSDQVTC
VDWRARKITKKGTVSLSELAEIKAKAKALIG

Download         Length: 336 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9053.46 Da        Isoelectric Point: 4.5680

>AT278964 WP_283656988.1 NZ_CP123368:c9311-9066 [Providencia rettgeri]
MTQVIVKKWGNSPSVRLPVAIMERASLNVDDTVEIDVEEGRIIITPVKAQEYSIDFLLGNITPENIHEKMDFGKATGKEL
I

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References